000			02303 a2200349 4500
003			OSt
005			20240304151124.0
008			240227b xxu||||| |||| 00| 0 eng d
020			_a9783031424212
040			_cIIT Kanpur
041			_aeng
082			_a547 _bP943 v.123
245			_aProgress in the chemistry of organic natural products [V.123] _cYoshiyasu Fukuyama, Miwa Kubo and Kenichi Harada ; edited by A. Douglas Kinghorn ...[et al.] _bneurotrophic natural products
260			_bSpringer _c2024 _aSwitzerland
300			_aix, 473p
440			_aProgress in the chemistry of organic natural products
490			_a/ edited by A. Douglas Kinghorn ...[et al.] _v; v.123
520			_aThis book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer’s disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products.
650			_aNatural products
650			_aOrganic chemistry
650			_aNeurotrophic
700			_aFukuyama, Yoshiyasu
700			_aKubo, Miwa
700			_aHarada, Kenichi
700			_aKinghorn, A. Douglas [ed.]
700			_aFalk, Heinz [ed.]
700			_aGibbons, Simon [ed.]
700			_aAsakawa, Yoshinori [ed.]
700			_aLiu, Ji-Kai [ed.]
700			_aDirsch, Verena M. [ed.]
942			_cBK
999			_c567073 _d567073