000			01695 a2200265 4500
003			OSt
020			_a9783030648527
040			_cIIT Kanpur
041			_aeng
082			_a547 _bP943
245			_aProgress in the chemistry of organic natural products [Vol. 115] _cedited by A. D. Kinghorn.. [et al.]
260			_bSpringer _c2021 _aSwitzerland
300			_avii, 203p
440			_aProgress in the chemistry of organic natural products/ edited by A. D. Kinghorn.. [et al.]
490			_a; v.115
520			_aThis book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
650			_aChemistry, Organic
700			_aKinghorn, A. Douglas [ed.]
700			_aFalk, Heinz [ed.]
700			_aGibbons, Simon [ed.]
700			_aAsakawa, Yoshinori [ed.]
700			_aLiu, Ji-Kai [ed.]
700			_aDirsch, Verena M. [ed.]
942			_cBK
999			_c564536 _d564536