000 03541nam a22005775i 4500
001 978-3-540-72110-9
003 DE-He213
005 20161121231203.0
007 cr nn 008mamaa
008 100301s2007 gw | s |||| 0|eng d
020 _a9783540721109
_9978-3-540-72110-9
024 7 _a10.1007/978-3-540-72110-9
_2doi
050 4 _aR856-857
072 7 _aMQW
_2bicssc
072 7 _aTEC009000
_2bisacsh
082 0 4 _a610.28
_223
245 1 0 _aBiopacemaking
_h[electronic resource] /
_cedited by J. A. E Spaan, Ruben Coronel, Jacques M. T. de Bakker, Antonio Zaza.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2007.
300 _aVIII, 182 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSeries in Biomedical Engineering,
_x1864-5763
505 0 _aBiopacemaking: Clinically Attractive, Scientifically a Challenge -- Embryological Development of Pacemaker Hierarchy and Membrane Currents Related to the Function of the Adult Sinus Node: Implications for Autonomic Modulation of Biopacemakers -- Creation of a Biological Pacemaker by Gene- or Cell-Based Approaches -- Creating a Cardiac Pacemaker by Gene Therapy -- Biological Pacemakers Based on If -- Gene Therapy to Create Biological Pacemakers -- Inhibition of Cardiomyocyte Automaticity by Electrotonic Application of Inward Rectifier Current from Kir2.1 Expressing Cells -- Propagation of Pacemaker Activity -- Computer Modelling of the Sinoatrial Node -- Application of Mesenchymal Stem Cell-Derived Cardiomyocytes as Bio-pacemakers: Current Status and Problems to Be Solved -- Enrichment of Cardiac Pacemaker-Like Cells: Neure gulin-1 and Cyclic amp Increase If-Current Density and Connexin 40 mRNA Levels in Fetal Cardiomyocytes.
520 _aThe development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well. This book gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use.
650 0 _aEngineering.
650 0 _aHuman physiology.
650 0 _aCardiology.
650 0 _aApplication software.
650 0 _aBiophysics.
650 0 _aBiological physics.
650 0 _aBiomedical engineering.
650 1 4 _aEngineering.
650 2 4 _aBiomedical Engineering.
650 2 4 _aHuman Physiology.
650 2 4 _aComputer Applications.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aCardiology.
700 1 _aSpaan, J. A. E.
_eeditor.
700 1 _aCoronel, Ruben.
_eeditor.
700 1 _aBakker, Jacques M. T. de.
_eeditor.
700 1 _aZaza, Antonio.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540721093
830 0 _aSeries in Biomedical Engineering,
_x1864-5763
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-540-72110-9
912 _aZDB-2-ENG
950 _aEngineering (Springer-11647)
999 _c509840
_d509840