000			03662nam a22005055i 4500
001			978-3-540-75809-9
003			DE-He213
005			20161121231146.0
007			cr nn 008mamaa
008			100609s2007 gw | s |||| 0|eng d
020			_a9783540758099 _9978-3-540-75809-9
024	7		_a10.1007/978-3-540-75809-9 _2doi
050		4	_aQD410-412.5
072		7	_aPNND _2bicssc
072		7	_aSCI013040 _2bisacsh
082	0	4	_a547.05 _223
245	1	0	_aDirected Metallation _h[electronic resource] / _cedited by Naoto Chatani.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2007.
300			_aXII, 206 p. 170 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aTopics in Organometallic Chemistry, _x1436-6002 ; _v24
505	0		_aCatalytic Addition of C?–?H Bonds to C?–?C Multiple Bonds -- Chelation-Assisted Arylation via C–H Bond Cleavage -- Catalytic Arylation and Vinylation Reactions Directed by Anionic Oxygen Functions via Cleavage of C?–?H and C?–?C Bonds -- Chelate-Directed Oxidative Functionalization of Carbon–Hydrogen Bonds: Synthetic Applications and Mechanistic Insights -- Directed C?–?C Bond Activation by Transition Metal Complexes -- Directed Rhodium-Catalyzed Hydroformylation of Alkenes -- Directed Mizoroki–Heck Reactions.
520			_aDirected metalation is recognized as one of the most useful methodologies for the regio- and stereoselective generation of organometallic species, the generation of which necessarily leads to the selective formation of organic products. Cyclometalation using Li, Mn, and Pd, and directed hydrometalation and carbometalation using Al and Zn, have been utilized for regio- and/or stereoselective synthesis for decades. Recently, a new chelation-assisted methodology has been developed not only for controlling regio- and stereoselectivity of reactions, but also for accelerating reactions. In particular, chelation-methodology has been utilized as a new activation method, in which a carbon-metal bond is generated directly from a C-H bond; a reaction rarely achieved using conventional methods. A wide variety of catalytic functionalization reactions of C-H bonds by the utilization of a chelation, have been developed recently and are comprehensively discussed in this book by leading experts. In addition, new approaches to directed hydrometalation and directed carbometalation as a key step are also discussed. A unique stereo- and regioselective hydroformylation has been developed through the utilization of directed hydrometalation. The regioselective Mizoroki-Heck reaction is another example in which directed carbometalation can be used to achieve a high regioselectivity. These examples emphasize how these innovative methodologies are contributing to different fields of chemistry.
650		0	_aChemistry.
650		0	_aInorganic chemistry.
650		0	_aOrganometallic chemistry.
650		0	_aMedicinal chemistry.
650		0	_aCatalysis.
650	1	4	_aChemistry.
650	2	4	_aOrganometallic Chemistry.
650	2	4	_aCatalysis.
650	2	4	_aInorganic Chemistry.
650	2	4	_aMedicinal Chemistry.
700	1		_aChatani, Naoto. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540758082
830		0	_aTopics in Organometallic Chemistry, _x1436-6002 ; _v24
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-75809-9
912			_aZDB-2-CMS
950			_aChemistry and Materials Science (Springer-11644)
999			_c509433 _d509433