000 03903nam a22005415i 4500
001 978-1-4020-5525-6
003 DE-He213
005 20161121231042.0
007 cr nn 008mamaa
008 100301s2008 ne | s |||| 0|eng d
020 _a9781402055256
_9978-1-4020-5525-6
024 7 _a10.1007/978-1-4020-5525-6
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
245 1 0 _aVoltage-Sensitive Ion Channels
_h[electronic resource] :
_bBiophysics of Molecular Excitability /
_cedited by H. Richard Leuchtag.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2008.
300 _aXXIV, 532 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aExploring Excitability -- Information In The Living Body -- Animal Electricity -- Electrophysiology Of The Axon -- Aspects Of Condensed Matter -- Ions In The Electric Field -- Ions Drift And Diffuse -- Multi-Ion And Transient Electrodiffusion -- Models Of Membrane Excitability -- Admittance To The Semicircle -- What's That Noise? -- Ion Channels, Proteins And Transitions -- Diversity And Structures Of Ion Channels -- Microscopic Models Of Channel Function -- Order From Disorder -- Polar Phases -- Delicate Phases And Their Transitions -- Propagation And Percolation In A Channel -- Screws And Helices -- Voltage-Induced Gating Of Ion Channels -- Branching Out.
520 _aThe goal of this book is to explore the complexity of a microscopic bit of matter that exists in a myriad of copies within our bodies, the voltage-sensitive ion channel. We seek to investigate the way in which these macromolecules make it possible for the long fibers of our nerve and muscle cells to conduct impulses. These integral components of cell membranes are marvels of nature's evolutionary adaptation. To understand them we must probe the boundaries of physics and chemistry. Since function is intimately related to structure, we examine the molecular structure of channels, focusing on physical principles that govern all matter. With the application of genetic methods, our knowledge of ion channels has broadened and deepened. In the hope that research can help ameliorate suffering, we discuss the diseases that arise from channel malfunctions due to genetic mutations. This book is intended for students and scientists who are willing to travel into uncharted waters of an interdisciplinary science. We approach the subject of volta- sensitive ion channels from various points of view. This book seeks to give voice to the viewpoints of the physical and the biological scientist, and to bridge gaps in terminology and background. Readers may find this book to have both elementary and advanced aspects: For the reader trained in the biological sciences, it reviews background in physics and chemistry; for the reader trained in the physical sciences, it reviews background in physiology and biochemistry.
650 0 _aPhysics.
650 0 _aBiochemistry.
650 0 _aAnimal physiology.
650 0 _aNeurobiology.
650 0 _aAmorphous substances.
650 0 _aComplex fluids.
650 0 _aBiophysics.
650 0 _aBiological physics.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aAnimal Physiology.
650 2 4 _aSoft and Granular Matter, Complex Fluids and Microfluidics.
650 2 4 _aAnimal Biochemistry.
650 2 4 _aNeurobiology.
700 1 _aLeuchtag, H. Richard.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402055249
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-5525-6
912 _aZDB-2-PHA
950 _aPhysics and Astronomy (Springer-11651)
999 _c507849
_d507849