000 03961nam a22006015i 4500
001 978-0-387-68919-7
003 DE-He213
005 20161121231039.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 _a9780387689197
_9978-0-387-68919-7
024 7 _a10.1007/0-387-68919-2
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
245 1 0 _aBiological Membrane Ion Channels
_h[electronic resource] :
_bDynamics, Structure, and Applications /
_cedited by Shin-Ho Chung, Olaf S. Andersen, Vikram Krishnamurthy.
264 1 _aNew York, NY :
_bSpringer New York,
_c2007.
300 _aXIV, 658 p. 168 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiological And Medical Physics Biomedical Engineering,
_x1618-7210
505 0 _aIon Channels, from Fantasy to Fact in Fifty Years1 -- Specific Channel Types -- Gramicidin Channels: Versatile Tools -- Voltage-Gated Ion Channels -- Voltage-Gated Potassium Channels -- BKCa-Channel Structure and Function -- Voltage-Gated Sodium Channels -- Calcium Channels -- Chloride Transporting CLC Proteins1 -- Ligand-Gated Ion Channels: Permeation and Activation1 -- Mechanosensitive Channels -- TRP Channels -- Ion Channels in Epithelial Cells -- Theoretical Approaches -- Poisson–Nernst–Planck Theory of Ion Permeation Through Biological Channels -- A Mesoscopic–Microscopic Perspective on Ion Channel Permeation Energetics: The Semi-Microscopic Approach1 -- Brownian Dynamics: Simulation for Ion Channel Permeation1 -- Molecular Dynamics Simulation Approaches to K Channels -- Emerging Technologies -- Patch-Clamp Technologies for Ion Channel Research -- Gated Ion Channel-Based Biosensor Device -- Signal Processing Based on Hidden Markov Models for Extracting Small Channel Currents.
520 _aIon channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences. Key Features Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels Uses schematic diagrams to illustrate important concepts in biophysics Written by leading researchers in the area of ion channel investigations.
650 0 _aPhysics.
650 0 _aNeurosciences.
650 0 _aBiotechnology.
650 0 _aBiochemistry.
650 0 _aNeurobiology.
650 0 _aBiophysics.
650 0 _aBiological physics.
650 0 _aBiomedical engineering.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aNeurosciences.
650 2 4 _aBiomedical Engineering.
650 2 4 _aNeurobiology.
650 2 4 _aBiotechnology.
650 2 4 _aAnimal Biochemistry.
700 1 _aChung, Shin-Ho.
_eeditor.
700 1 _aAndersen, Olaf S.
_eeditor.
700 1 _aKrishnamurthy, Vikram.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387333236
830 0 _aBiological And Medical Physics Biomedical Engineering,
_x1618-7210
856 4 0 _uhttp://dx.doi.org/10.1007/0-387-68919-2
912 _aZDB-2-PHA
950 _aPhysics and Astronomy (Springer-11651)
999 _c507780
_d507780