000 03767nam a22005055i 4500
001 978-3-540-26511-5
003 DE-He213
005 20161121230945.0
007 cr nn 008mamaa
008 100301s2005 gw | s |||| 0|eng d
020 _a9783540265115
_9978-3-540-26511-5
024 7 _a10.1007/b137722
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
245 1 0 _aBiophysical Aspects of Transmembrane Signaling
_h[electronic resource] /
_cedited by Sandor Damjanovich.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2005.
300 _aXVIII, 322 p. 41 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Series in Biophysics,
_x0932-2353 ;
_v8
505 0 _aThe Impact of Environmental Signals on the Growth and Survival of Human T Cells -- Novel Single Cell Fluorescence Approaches in the Investigation of Signaling at the Cellular Level -- Non-Random Patterns of Membrane Proteins and Their Roles in Transmembrane Signaling -- Transmembrane Signals Mediated by IL-2 and IL-15 Control the Life and Death of Lymphocytes -- Single-Molecule Imaging of Diffusion, Recruitment, and Activation of Signaling Molecules in Living Cells -- Chemokine Signaling: The Functional Importance of Stabilizing Receptor Conformations -- Signaling and Reverse Signaling in the Tumor Necrosis Factor/TNF Receptor System -- Regulation of Immunoreceptor Activities: The Paradigm of the Type I Fc? Receptor -- Histamine Receptors and Signaling -- Signal Transduction by Ion Channels in Lymphocytes.
520 _aTransmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the side of a high number of complex biochemical events and an equally high number of physical changes at molecular and cellular levels at the same time. Both types of researchers were convinced that their findings are the most decisive, having higher importance than the findings of the other scientist population. Both casts were wrong. Life, even at cellular level, has a number of interacting physical and biochemical mechanisms, which finally build up the creation of an "excited" cell that will respond to particular signals from the outer or inner world. This book handles both aspects of the signalling events, and in some cases tries to unify our concepts and help understand the signals that govern the life and death of our cells. Not only the understanding, but also the interference (e.g. medication) may depend on the full knowledge of both sides. These above statements are supported by the application of highly diverse physical and biochemical technologies demonstrated and explained by experts who are pioneers of their particular scientific field.
650 0 _aPhysics.
650 0 _aBiochemistry.
650 0 _aCell biology.
650 0 _aBiophysics.
650 0 _aBiological physics.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aCell Biology.
650 2 4 _aBiochemistry, general.
700 1 _aDamjanovich, Sandor.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540250647
830 0 _aSpringer Series in Biophysics,
_x0932-2353 ;
_v8
856 4 0 _uhttp://dx.doi.org/10.1007/b137722
912 _aZDB-2-PHA
950 _aPhysics and Astronomy (Springer-11651)
999 _c506437
_d506437