000			03742nam a22006015i 4500
001			978-0-387-33916-0
003			DE-He213
005			20161121230939.0
007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9780387339160 _9978-0-387-33916-0
024	7		_a10.1007/0-387-33916-7 _2doi
050		4	_aQH505
072		7	_aPHVN _2bicssc
072		7	_aPHVD _2bicssc
072		7	_aSCI009000 _2bisacsh
082	0	4	_a571.4 _223
100	1		_aKoonin, Eugene V. _eauthor.
245	1	0	_aPower Laws, Scale-Free Networks and Genome Biology _h[electronic resource] / _cby Eugene V. Koonin, Yuri I. Wolf, Georgy P. Karev.
264		1	_aBoston, MA : _bSpringer US, _c2006.
300			_aXVI, 258 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMolecular Biology Intelligence Unit
505	0		_aPower Laws in Biological Networks -- Graphical Analysis of Biocomplex Networks and Transport Phenomena -- Large-Scale Topological Properties of Molecular Networks -- The Connectivity of Large Genetic Networks -- The Drosophila Protein Interaction Network May Be neither Power-Law nor Scale-Free -- Birth and Death Models of Genome Evolution -- Scale-Free Evolution -- Gene Regulatory Networks -- Power Law Correlations in DNA Sequences -- Analytical Evolutionary Model for Protein Fold Occurrence in Genomes, Accounting for the Effects of Gene Duplication, Deletion, Acquisition and Selective Pressure -- The Protein Universes -- The Role of Computation in Complex Regulatory Networks -- Neutrality and Selection in the Evolution of Gene Families -- Scaling Laws in the Functional Content of Genomes.
520			_aPower Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.
650		0	_aPhysics.
650		0	_aBiochemistry.
650		0	_aProteomics.
650		0	_aBioinformatics.
650		0	_aMicrobial genetics.
650		0	_aMicrobial genomics.
650		0	_aBiophysics.
650		0	_aBiological physics.
650	1	4	_aPhysics.
650	2	4	_aBiophysics and Biological Physics.
650	2	4	_aBioinformatics.
650	2	4	_aBiochemistry, general.
650	2	4	_aMicrobial Genetics and Genomics.
650	2	4	_aProteomics.
650	2	4	_aPhysics, general.
700	1		_aWolf, Yuri I. _eauthor.
700	1		_aKarev, Georgy P. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387258836
830		0	_aMolecular Biology Intelligence Unit
856	4	0	_uhttp://dx.doi.org/10.1007/0-387-33916-7
912			_aZDB-2-PHA
950			_aPhysics and Astronomy (Springer-11651)
999			_c506304 _d506304