000			03459nam a22005415i 4500
001			978-3-540-79478-3
003			DE-He213
005			20161121230849.0
007			cr nn 008mamaa
008			100301s2008 gw | s |||| 0|eng d
020			_a9783540794783 _9978-3-540-79478-3
024	7		_a10.1007/978-3-540-79478-3 _2doi
050		4	_aRC254-282
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a616.994 _223
245	1	0	_aOncogenes Meet Metabolism _h[electronic resource] : _bFrom Deregulated Genes to a Broader Understanding of Tumour Physiology / _cedited by G. Kroemer, D. Mumberg, H. Keun, B. Riefke, T. Steger-Hartmann, K. Petersen.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_aXV, 265 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aErnst Schering Foundation Symposium Proceedings, _x0947-6075 ; _v2007/4
505	0		_aMitochondria and Cancer -- Role of the Metabolic Stress Responses of Apoptosis and Autophagy in Tumor Suppression -- The Interplay Between MYC and HIF in the Warburg Effect -- Using Metabolomics to Monitor Anticancer Drugs -- Biomarker Discovery for Drug Development and Translational Medicine Using Metabonomics -- Pyruvate Kinase Type M2: A Key Regulator Within the Tumour Metabolome and a Tool for Metabolic Profiling of Tumours -- Molecular Imaging of Tumor Metabolism and Apoptosis -- Minimally Invasive Biomarkers for Therapy Monitoring -- Use of Metabolic Pathway Flux Information in Anticancer Drug Design -- Cancer Diagnostics Using 1H-NMR-Based Metabonomics -- Human Metabolic Phenotyping and Metabolome Wide Association Studies -- Defining Personal Nutrition and Metabolic Health Through Metabonomics.
520			_aIn 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
650		0	_aMedicine.
650		0	_aHuman physiology.
650		0	_aAnalytical chemistry.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
650	2	4	_aHuman Physiology.
650	2	4	_aAnalytical Chemistry.
700	1		_aKroemer, G. _eeditor.
700	1		_aMumberg, D. _eeditor.
700	1		_aKeun, H. _eeditor.
700	1		_aRiefke, B. _eeditor.
700	1		_aSteger-Hartmann, T. _eeditor.
700	1		_aPetersen, K. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540794776
830		0	_aErnst Schering Foundation Symposium Proceedings, _x0947-6075 ; _v2007/4
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-79478-3
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c505091 _d505091