000 03156nam a22005295i 4500
001 978-3-540-77768-7
003 DE-He213
005 20161121230849.0
007 cr nn 008mamaa
008 100301s2008 gw | s |||| 0|eng d
020 _a9783540777687
_9978-3-540-77768-7
024 7 _a10.1007/978-3-540-77768-7
_2doi
050 4 _aRC902-918
072 7 _aMJR
_2bicssc
072 7 _aMED055000
_2bisacsh
082 0 4 _a616.61
_223
100 1 _aMoritz, Karen M.
_eauthor.
245 1 0 _aFactors Influencing Mammalian Kidney Development: Implications for Health in Adult Life
_h[electronic resource] /
_cby Karen M. Moritz, Marelyn Wintour-Coghlan, M. Jane Black, John F. Bertram, Georgina Caruana.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2008.
300 _aIX, 79 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Anatomy Embryology and Cell Biology,
_x0301-5556 ;
_v196
505 0 _aMorphological Development of the Mammalian Kidney -- Genetic Regulation of Metanephric Development -- Abnormalities of Renal Development in the Human -- Methodology to Examine Kidney Development -- Development of Function in the Fetus -- Nephron Endowment -- Developmental Programming of the Kidney -- Future Directions.
520 _aIn this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. In addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. In addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. The consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. The epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aHuman physiology.
650 0 _aNephrology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aNephrology.
650 2 4 _aHuman Physiology.
650 2 4 _aHuman Genetics.
700 1 _aWintour-Coghlan, Marelyn.
_eauthor.
700 1 _aBlack, M. Jane.
_eauthor.
700 1 _aBertram, John F.
_eauthor.
700 1 _aCaruana, Georgina.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540777670
830 0 _aAdvances in Anatomy Embryology and Cell Biology,
_x0301-5556 ;
_v196
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-540-77768-7
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c505081
_d505081