000			03335nam a22005655i 4500
001			978-3-540-73493-2
003			DE-He213
005			20161121230848.0
007			cr nn 008mamaa
008			100301s2008 gw | s |||| 0|eng d
020			_a9783540734932 _9978-3-540-73493-2
024	7		_a10.1007/978-3-540-73493-2 _2doi
050		4	_aQH432
072		7	_aPSVH _2bicssc
072		7	_aPSAK1 _2bicssc
072		7	_aSCI070000 _2bisacsh
072		7	_aSCI029000 _2bisacsh
082	0	4	_a591.35 _223
245	1	0	_aProgestins and the Mammary Gland _h[electronic resource] : _bFrom Basic Science to Clinical Applications / _cedited by O. Conneely, C. Otto.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_aXVII, 199 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aErnst Schering Foundation Symposium Proceedings, _x0947-6075 ; _v2007/1
505	0		_aDynamic Regulation of Progesterone Receptor Activity in Female Reproductive Tissues -- Steroid Receptor Coactivator 2: An Essential Coregulator of Progestin-Induced Uterine and Mammary Morphogenesis -- Inhibition of Mammary Tumorigenesis by Estrogen and Progesterone in Genetically Engineered Mice -- Estrogens, Progestins, and Risk of Breast Cancer -- Mammary Development, Carcinomas and Progesterone: Role of Wnt Signalling -- Progesterone Signaling in Mammary Gland Development -- Progesterone Receptor Isoforms in Normal and Malignant Breast -- In Vivo Characterization of Progestins with Reduced Non-genomic Activity In Vitro -- In Vitro and In Vivo Characterization of a Novel Nonsteroidal, Species-Specific Progesterone Receptor Modulator, PRA-910.
520			_aProgestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.
650		0	_aLife sciences.
650		0	_aMolecular biology.
650		0	_aPharmacology.
650		0	_aEndocrinology.
650		0	_aReproductive medicine.
650		0	_aAnimal genetics.
650	1	4	_aLife Sciences.
650	2	4	_aAnimal Genetics and Genomics.
650	2	4	_aReproductive Medicine.
650	2	4	_aEndocrinology.
650	2	4	_aMolecular Medicine.
650	2	4	_aPharmacology/Toxicology.
700	1		_aConneely, O. _eeditor.
700	1		_aOtto, C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540734925
830		0	_aErnst Schering Foundation Symposium Proceedings, _x0947-6075 ; _v2007/1
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-73493-2
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c505058 _d505058