000			03644nam a22005175i 4500
001			978-1-59745-420-9
003			DE-He213
005			20161121230841.0
007			cr nn 008mamaa
008			100301s2008 xxu| s |||| 0|eng d
020			_a9781597454209 _9978-1-59745-420-9
024	7		_a10.1007/978-1-59745-420-9 _2doi
050		4	_aRC952-954.6
072		7	_aMJX _2bicssc
072		7	_aMED032000 _2bisacsh
082	0	4	_a618.97 _223
082	0	4	_a612.67 _223
245	1	0	_aOxidative Stress in Aging _h[electronic resource] : _bFrom Model Systems to Human Diseases / _cedited by Satomi Miwa, Kenneth B. Beckman, Florian L. Muller.
264		1	_aTotowa, NJ : _bHumana Press, _c2008.
300			_aVIII, 320 p. 28 illus., 1 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAging Medicine
505	0		_aThe Basics of Oxidative Biochemistry -- The Role of Oxidative Stress in Aging -- Retrograde Response, Oxidative Stress, and Cellular Senescence -- Reactive Oxygen Species in Molecular Pathways Controlling Aging in the Filamentous Fungus Podospora anserina -- Oxidative Stress and Aging in the Budding Yeast Saccharomyces cerevisiae -- Oxidative Stress and Aging in the Nematode Caenorhabditis elegans -- Roles of Oxidative Stress in the Aging Process of Drosophila melanogaster -- Does Oxidative Stress Limit Mouse Life Span? -- Mitochondrial Free Radical Production and Caloric Restriction: Implications in Vertebrate Longevity and Aging -- Oxidative Stress in Human Aging and Diseases -- Deregulation of Mitochondrial Function: A Potential Common Theme for Cardiovascular Disease Development -- Oxidative Stress in Type 2 Diabetes Mellitus -- DNA Oxidative Damage and Cancer -- Oxidative Stress in Hypertension -- Aging and Cardiac Ischemia—Mitochondria and Free Radical Considerations -- Role of the Antioxidant Network in the Prevention of Age-Related Diseases -- Future -- Reactive Oxygen Species as Signaling Molecules -- Summary and Outlook.
520			_aOxidative Stress in Aging: From Model Systems to Human Diseases discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). Human aging is a complex phenomenon - not everyone gets the same diseases and dies from the same cause. Accumulating reports implicate the connection between free radicals and various diseases and age-related pathological conditions. Although the causal relationships have not been established, it is necessary to discuss how free radicals are involved in each situation. In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.
650		0	_aMedicine.
650		0	_aInternal medicine.
650		0	_aGeriatrics.
650		0	_aCell biology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aGeriatrics/Gerontology.
650	2	4	_aInternal Medicine.
650	2	4	_aCell Biology.
700	1		_aMiwa, Satomi. _eeditor.
700	1		_aBeckman, Kenneth B. _eeditor.
700	1		_aMuller, Florian L. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588299918
830		0	_aAging Medicine
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59745-420-9
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c504901 _d504901