000 04013nam a22005055i 4500
001 978-1-59745-336-3
003 DE-He213
005 20161121230841.0
007 cr nn 008mamaa
008 100301s2008 xxu| s |||| 0|eng d
020 _a9781597453363
_9978-1-59745-336-3
024 7 _a10.1007/978-1-59745-336-3
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 4 _aThe Role of Microtubules in Cell Biology, Neurobiology, and Oncology
_h[electronic resource] /
_cedited by Tito Fojo.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2008.
300 _aXVII, 587 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Drug Discovery and Development
505 0 _aAn Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly -- Molecular Mechanisms of Microtubule Acting Cancer Drugs -- Microtubule Dynamics -- Microtubule-Associated Proteins and Microtubule-Interacting Proteins -- The Post-Translational Modifications of Tubulin -- The Isotypes of Tubulin -- The Tubulin Superfamily -- Tubulin Proteomics in Cancer -- Tubulin and Microtubule Structures -- Destabilizing Agents -- Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin -- Antimicrotubule Agents That Bind Covalently to Tubulin -- Microtubule Stabilizing Agents -- Mechanisms of Resistance to Drugs That Interfere with Microtubule Assembly -- Resistance to Microtubule-Targeting Drugs -- Microtubule Stabilizing Agents in Clinical Oncology -- Investigational Anticancer Agents Targeting the Microtubule -- Microtubule Damaging Agents and Apoptosis -- Microtubule Targeting Agents and the Tumor Vasculature -- Neurodegenerative Diseases -- Structure, Function, and Regulation of the Microtubule Associated Protein Tau.
520 _aThe family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investigation is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available. Among the topics examined in this volume are compounds that interact with tubulin, mechanisms and regulation by microtubule-associated proteins and drugs, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases. Without the basic scientific knowledge that has been accumulated – to which the contributors of this work have contributed greatly – we would not be in the position we find ourselves as we increasingly understand disease and advancing therapies. Microtubule Targets in Cancer Therapy contributes to this new knowledge, and the text will be an invaluable resource for cancer researchers, oncologists, pharmacologists, and medical chemists.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aPharmacology.
650 0 _aMedicinal chemistry.
650 0 _aOncology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aOncology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMedicinal Chemistry.
700 1 _aFojo, Tito.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781588292940
830 0 _aCancer Drug Discovery and Development
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-59745-336-3
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c504886
_d504886