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001			978-1-59745-309-7
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008			100301s2008 xxu| s |||| 0|eng d
020			_a9781597453097 _9978-1-59745-309-7
024	7		_a10.1007/978-1-59745-309-7 _2doi
050		4	_aRC648-665.2
072		7	_aMJG _2bicssc
072		7	_aMED027000 _2bisacsh
082	0	4	_a616.4 _223
245	1	0	_aGenomics in Endocrinology _h[electronic resource] : _bDNA Microarray Analysis in Endocrine Health and Disease / _cedited by Stuart Handwerger, Bruce Aronow.
264		1	_aTotowa, NJ : _bHumana Press, _c2008.
300			_aXI, 288 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aContemporary Endocrinology
505	0		_aMicroarray-based Gene Expression Analysis of Endocrine Systems: Principles of Experimental Design and Interpretation -- Hormone Action and Molecular Mechanisms -- Gene Expression Profiles and Transcription Factors Involved in Parathyroid Hormone Signaling in Osteoblastic Cells -- Analysis of Growth Hormone Effects on Hepatic Gene Expression in Hypophysectomized Rats -- Gene Expression Profiling in Leiomyoma in Response to GnRH Therapy and TGF-? -- Gene Profiling Analysis of Androgen Receptor Mediated Function -- Interrogating Estrogen Receptor ? Signaling in Breast Cancer by Chromatin Immunoprecipitation Microarrays -- Gene Expression Analysis of the Adrenal Cortex in Health and Disease -- Endocrine Producing Tissues -- DNA Microarray Analysis of Human Uterine Decidualization -- Large-scale DNA Microarray Data Analysis Reveals Glucocorticoid Receptor-mediated Breast Cancer Cell Survival Pathways -- Application of Microarrays for Gene Transcript Analysis in Type 2 Diabetes -- DNA Microarray Analysis of Effects of TSH, Iodide, Cytokines, and Therapeutic Agents on Gene Expression in Cultured Human Thyroid Follicles -- Diseases of Hormonal Systems -- Genomics and Polycystic Ovary Syndrome (PCOS): The Use of Microarray Analysis to Identify New Candidate Genes -- Microarray Analysis of Alterations Induced by Obesity in White Adipose Tissue Gene Expression Profiling -- Novel Molecular Signaling and Classification of Human Clinically Nonfunctioning Pituitary Adenomas Identified by Microarray and Reverse Transcription-Quantitative Polymerase Chain Reaction -- Gene Expression Studies of Prostate Hyperplasia in Prolactin Transgenic Mice.
520			_aIn recent years, the development of new technologies capable of monitoring genome function has resulted in fewer hopeful estimates and increasingly solid depictions of genome output from individual samples. Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general methods for the analysis of microarray data, as well as studies of a wide variety of normal and abnormal endocrine cells. In the introductory chapter, the volume’s editors describe several issues in hypothesis formulation, experimental design, data analysis, and follow-up studies that may corroborate, validate, and extend hypotheses gained through microarray analyses. The contributed chapters span a variety of applications that we have divided into the areas of (1) genomic insights into molecular mechanisms responsible for hormone action, (2) genomic characterizations of endocrine producing tissues, and (3) genomic manifestations of diseases of hormonal systems. A volume on the cutting-edge of technology, Genomics in Endocrinology will provide researchers with an authoritative volume on the most recent advances in monitoring genome function.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aEndocrinology.
650		0	_aCell biology.
650		0	_aMicrobiology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aEndocrinology.
650	2	4	_aCell Biology.
650	2	4	_aHuman Genetics.
650	2	4	_aMicrobiology.
700	1		_aHandwerger, Stuart. _eeditor.
700	1		_aAronow, Bruce. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588296511
830		0	_aContemporary Endocrinology
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59745-309-7
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c504882 _d504882