| 000 | 06677nam a22005055i 4500 | ||
|---|---|---|---|
| 001 | 978-1-59745-293-9 | ||
| 003 | DE-He213 | ||
| 005 | 20161121230840.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s2008 xxu| s |||| 0|eng d | ||
| 020 |
_a9781597452939 _9978-1-59745-293-9 |
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| 024 | 7 |
_a10.1007/978-1-59745-293-9 _2doi |
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| 050 | 4 | _aRC254-282 | |
| 072 | 7 |
_aMJCL _2bicssc |
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| 072 | 7 |
_aMED062000 _2bisacsh |
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| 082 | 0 | 4 |
_a616.994 _223 |
| 245 | 1 | 0 |
_aTransforming Growth Factor-β in Cancer Therapy, Volume II _h[electronic resource] : _bCancer Treatment and Therapy / _cedited by Sonia B. Jakowlew. |
| 264 | 1 |
_aTotowa, NJ : _bHumana Press, _c2008. |
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| 300 |
_aXXVI, 786 p. 164 illus., 4 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 | _aCancer Drug Discovery and Development | |
| 505 | 0 | _aTransforming Growth Factor-? In Developing and Advanced Cancers -- Transforming Growth Factor-? Signaling in Pancreas Development and Pancreatic Disease -- Role of Transforming Growth Factor-? in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma -- TGF-?, Smads and Cervical Cancer -- TGF-? Signaling and Biglycan in Pancreatic Cancer -- TGF-? Signaling in Endometrial Cancer -- TGF-? Ligands, TGF-? Receptors, and Lung Cancer -- Role of TGF-? in Osteolytic Bone Metastases -- Hormonal Regulation of Transforming Growth Factor-? in Breast Cancer -- TGF-? and Progression of Esophageal Cancer -- TGF-? and HER2/ErbB2 and Breast Cancer Progression -- TGF-? Dependent T-Cell Regulation in Colitis and Colon Cancer -- Role of Transforming Growth Factor-? in the Kidney — Physiology and Pathology -- Perturbations of TGF-? Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis -- Transforming Growth Factor-? in Brain Functions and Dysfunctions -- Inhibition of TGF-? Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment -- Key Roles of TGF-? and Smad3 in Prostate Cancer -- Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-? Type I Receptor -- Transforming Growth Factor-? in Cancer Treatment and Therapy -- High-Throughput Screening of Protein Interaction Networks in the TGF? Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression -- Tumor Suppressor and Pro-progression Roles for TGF-? in Breast Cancer -- Tumor Suppressors p53 and TGF? Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker -- TGF?: Roles in DNA Damage Responses -- The Rationale for and Effects of Targeting TGF-? for Glioma Therapy -- Tumor Suppressor Functions of TGF?1 in T Cells -- Therapeutic Effects of Adenovirus-Mediated Gene Transfer of TGF-? Signal Antagonists on Undesirable Epithelial-Mesenchymal Transition and Neovascularization -- Role of TGF-? in Tumor Protection and Antitumor Immunity -- Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1 -- Cancer-Associated Fibroblasts and the Role of TGF-? -- Adoptive Transfer of Tumor Reactive TGF-? Insensitive CD8+ T-cells for Cancer Therapy -- DNA Methylation and Histone Deacetylation Inhibitors as Potential Therapeutic Agents for the Reconstitution of TGF-? Signaling in Breast Cancer -- Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-?, Connective Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities -- TGF-? Signaling and Vascular Morphogenesis -- Aberrant Transforming Growth Factor-? Signaling in Human Pancreatic Cancer: Translational Implications -- TGF-? and Stromal Influences Over Local Tumor Invasion -- TGF-? at the Crossroads Between Inflammation, Suppression and Cancer -- Development of Inhibitors of Transforming Growth Factor-? Signaling for Therapy -- Transforming Growth Factor-? (TGF-?) Signaling Inhibitors in Cancer Therapy -- Targeting TGF-? as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy -- Targeting Transforming Growth Factor-? in Metastasis: In Vitro and In Vivo Mechanisms -- Targeted Downregulation of TGF-?2 with AP 12009 in Tumor Therapy -- Modulating TGF-? Receptor Signaling: A Novel Approach of Cancer Therapy -- Engineering TGF-? Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-? Action -- The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology -- Soluble Type II Transforming Growth Factor-? Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity -- Reversal of EMT by Small-Molecule Inhibitors of TGF-? Type I and II Receptors: Implications for Carcinoma Treatment -- Soluble TGF-? Type III Receptor Suppresses Malignant Progression of Human Cancer Cells -- Targeting Smad-Dependent TGF-? Signaling with Peptide Aptamers -- Rationale for Anti-TGF-? Antibody Therapy in Oncology. | |
| 520 | _aTransforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor-ß in developing and advanced cancers. Part II details transforming growth factor-ß in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor-ß signaling for therapy. This volume’s companion, Basic and Clinical Biology, examines transforming growth factor-ß signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aCancer research. | |
| 650 | 0 | _aOncology. | |
| 650 | 0 | _aPathology. | |
| 650 | 0 | _aCell biology. | |
| 650 | 1 | 4 | _aMedicine & Public Health. |
| 650 | 2 | 4 | _aOncology. |
| 650 | 2 | 4 | _aCancer Research. |
| 650 | 2 | 4 | _aCell Biology. |
| 650 | 2 | 4 | _aPathology. |
| 700 | 1 |
_aJakowlew, Sonia B. _eeditor. |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781588297150 |
| 830 | 0 | _aCancer Drug Discovery and Development | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-59745-293-9 |
| 912 | _aZDB-2-SME | ||
| 950 | _aMedicine (Springer-11650) | ||
| 999 |
_c504878 _d504878 |
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