000 04005nam a22005655i 4500
001 978-1-4020-6768-6
003 DE-He213
005 20161121230839.0
007 cr nn 008mamaa
008 100301s2008 ne | s |||| 0|eng d
020 _a9781402067686
_9978-1-4020-6768-6
024 7 _a10.1007/978-1-4020-6768-6
_2doi
050 4 _aQP34-38
072 7 _aMFG
_2bicssc
072 7 _aMED075000
_2bisacsh
082 0 4 _a612
_223
100 1 _aSchiaffino, Stefano.
_eauthor.
245 1 0 _aSkeletal Muscle Repair and Regeneration
_h[electronic resource] /
_cby Stefano Schiaffino, Terence Partridge.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2008.
300 _aXIII, 379 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Muscle Research,
_x1571-5663 ;
_v3
505 0 _aMyogenesis – The Early Years -- The Origin and Genetic Regulation of Myogenic Cells: From the Embryo to the Adult -- The Muscle Satellite Cell: The Story of a Cell on the Edge! -- Non Muscle Stem Cells and Muscle Regeneration -- Transcriptional Cascades in Muscle Regeneration -- The Ins and Outs of Satellite Cell Myogenesis: The Role of the Ruling Growth Factors -- Relaying the Signal During Myogenesis: Intracellular Mediators and Targets -- Muscle Regeneration in Animal Models -- Skeletal Muscle Reconstitution During Limb and Tail Regeneration in Amphibians: Two Contrasting Mechanisms -- Muscle Fibre Regeneration in Human Skeletal Muscle Diseases -- Skeletal Muscle Repair After Exercise-Induced Injury -- Inflammation in Skeletal Muscle Regeneration -- Complexity of Extracellular Matrix and Skeletal Muscle Regeneration -- Innervation of Regenerating Muscle -- Boosting Muscle Regeneration -- Age-Dependent Changes in Skeletal MuscleRegeneration.
520 _aSkeletal muscle is the most abundant tissue of our body. Apart from its essential role in locomotion, it is also the body’s main store of carbohydrate and protein as well as being one of the principal generators of heat. Its proper maintenance and function are, therefore, essential. A severe acute loss of muscle function is potentially lethal and the debilitating effects of chronic decline in mobility are commonplace experience, so repair and maintenance of the tissue must by both rapid and effective. Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology. The topics range from correlation of changes in pattern of gene expression with the histological sequence during a regenerative episode to the distinctive insult-specific patterns of structural and functional outcome at the other end of the spectrum. The middle ground – who is doing what in this complex process – constitutes the meat of this sandwich.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aMolecular biology.
650 0 _aNeurology.
650 0 _aSports medicine.
650 0 _aCell biology.
650 0 _aDevelopmental biology.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Physiology.
650 2 4 _aNeurology.
650 2 4 _aMolecular Medicine.
650 2 4 _aCell Biology.
650 2 4 _aDevelopmental Biology.
650 2 4 _aSports Medicine.
700 1 _aPartridge, Terence.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402067679
830 0 _aAdvances in Muscle Research,
_x1571-5663 ;
_v3
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-6768-6
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c504841
_d504841