000 03508nam a22005175i 4500
001 978-1-4020-6650-4
003 DE-He213
005 20161121230839.0
007 cr nn 008mamaa
008 100301s2008 ne | s |||| 0|eng d
020 _a9781402066504
_9978-1-4020-6650-4
024 7 _a10.1007/978-1-4020-6650-4
_2doi
050 4 _aRB45
072 7 _aMJF
_2bicssc
072 7 _aMED038000
_2bisacsh
082 0 4 _a616.15
_223
100 1 _aMalone, P. Colm.
_eauthor.
245 1 4 _aThe Aetiology of Deep Venous Thrombosis
_h[electronic resource] :
_bA Critical, Historical and Epistemological Survey /
_cby P. Colm Malone, Paul S. Agutter.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2008.
300 _aXXI, 318 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _ato the Study of Deep Venous Thrombosis -- The Coagulation Cascade and the Consensus Model of DVT -- Hypercoagulability -- Historical Roots -- Coagulation and its Disorders: A History of Haematological Research -- Virchow and the Pathophysiological Tradition in the 19th Century -- The Pathophysiological Tradition after Virchow -- Interrupted Circulation: The ‘Stasis’ Hypothesis and the Significance of Venous Valves -- Underperfusion of Valve Pockets and the Initiation of DVT -- The Role of Endothelial Hypoxia in DVT -- The Valve Cusp Hypoxia Hypothesis -- Molecular Changes in the Hypoxic Endothelium -- Cadaver Clots or Agonal Thrombi?.
520 _aWhat we now call ‘deep venous thrombosis’ (DVT) has been studied in diverse ways during the last 200–300 years. Each of these approaches contributes to a full modern understanding of aetiology. Therefore, much of this book is a historical survey of the field. However, our remit is broader than the title might suggest: the evolution of ideas about DVT is typical in many ways of medical biology as a whole. Thus, although the aetiology of DVT may seem a narrow topic for a monograph – it implicitly excludes arterial thrombosis and marginalises prophylaxis, therapy, and even such clinically significant sequelae as pulmonary embolism – we hope to engage the reader in a much more general inquiry. Our historical investigation reveals a 160-year-old schism between two contrasting philosophies of medical and biological research, a schism that is particularly – but by no means uniquely – relevant to the study of DVT. In principle, these philosophies should be complementary rather than competing. So while we wish to elucidate the aetiology of DVT per se, we are also concerned with a more abstract and wide-ranging issue: the future accommodation or rapprochement between two conceptual and methodological traditions.
650 0 _aMedicine.
650 0 _aMedicine
_xPhilosophy.
650 0 _aHematology.
650 0 _aPathology.
650 0 _aVascular surgery.
650 0 _aMedicine
_xHistory.
650 1 4 _aMedicine & Public Health.
650 2 4 _aHematology.
650 2 4 _aPathology.
650 2 4 _aHistory of Medicine.
650 2 4 _aVascular Surgery.
650 2 4 _aPhilosophy of Medicine.
700 1 _aAgutter, Paul S.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402066498
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-6650-4
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c504838
_d504838