000			04496nam a22005655i 4500
001			978-1-4020-6561-3
003			DE-He213
005			20161121230839.0
007			cr nn 008mamaa
008			100301s2008 ne | s |||| 0|eng d
020			_a9781402065613 _9978-1-4020-6561-3
024	7		_a10.1007/978-1-4020-6561-3 _2doi
050		4	_aRC1-1245
072		7	_aMJ _2bicssc
072		7	_aMED045000 _2bisacsh
082	0	4	_a616 _223
245	1	4	_aThe Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism _h[electronic resource] / _cedited by Bharti Mackness, Mike Mackness, Michael Aviram, György Paragh.
264		1	_aDordrecht : _bSpringer Netherlands, _c2008.
300			_aXV, 325 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProteins And Cell Regulation ; _v6
505	0		_aThe Bert La Du Memorial Lecture -- Paraoxonases: An Historical Perspective -- PONs and Atherosclerosis -- Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form -- Paraoxonase-1 and Cardiovascular Disease -- Oxidative Stress & Antioxidants and PON1 in Health and Disease -- D-4F Increases Paraoxonase 1 Activity in HDL -- Paraoxonase 1 (PON1), A Junction Between the Metabolisms of Homocysteine and Lipids -- The Role of PON2 and PON3 in Atherosclerosis and Related Traits -- Paraoxonase 1 and Postprandial Lipemia -- PON1 Genotypes and Coronary Heart Disease -- PON1 Structure -- Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents -- Stabilisation of Active Form of Natural Human PON1 Requires HPBP -- PONs in Disease other than Atherosclerosis -- Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection -- Age-Related Alterations in PON1 -- PON and Toxicology -- Paraoxonase (PON1) and Organophosphate Toxicity -- Implications of Paraoxonase-1 (PON1) Activity and Polymorphisms on Biochemical and Clinical Outcomes in Workers Exposed to Pesticides -- PON-Genetics and Regulation -- Transcriptional Regulation of the Paraoxonase Genes -- Effect of Lipid Lowering Medications on PON1 -- The Functional Consequences of Polymorphisms in the Human PON1 Gene -- Dietary Modulation of Paraoxonase-1 Activity and Concentration in Humans -- PONs Biochemistry -- PONs’ Natural Substrates – The Key for their Physiological Roles -- Paraoxonases, Quorum Sensing, And Pseudomonas Aeruginosa.
520			_aResearch into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research.
650		0	_aMedicine.
650		0	_aInternal medicine.
650		0	_aCardiology.
650		0	_aDiabetes.
650		0	_aMetabolic diseases.
650		0	_aMedical biochemistry.
650	1	4	_aMedicine & Public Health.
650	2	4	_aInternal Medicine.
650	2	4	_aCardiology.
650	2	4	_aDiabetes.
650	2	4	_aMetabolic Diseases.
650	2	4	_aMedical Biochemistry.
700	1		_aMackness, Bharti. _eeditor.
700	1		_aMackness, Mike. _eeditor.
700	1		_aAviram, Michael. _eeditor.
700	1		_aParagh, György. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402065606
830		0	_aProteins And Cell Regulation ; _v6
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4020-6561-3
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c504837 _d504837