000 03520nam a22005775i 4500
001 978-3-540-31916-0
003 DE-He213
005 20161121230823.0
007 cr nn 008mamaa
008 100806s2005 gw | s |||| 0|eng d
020 _a9783540319160
_9978-3-540-31916-0
024 7 _a10.1007/b98750
_2doi
050 4 _aRB1-214
072 7 _aMMF
_2bicssc
072 7 _aMED067000
_2bisacsh
082 0 4 _a616.07
_223
245 1 0 _aReactions, Processes
_h[electronic resource] :
_bOxidants and Antioxidant Defense Systems /
_cedited by Tilman Grune.
246 3 _aWith contribution by numerous experts
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2005.
300 _aXVI, 240 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aThe Handbook of Environmental Chemistry,
_x1433-6855 ;
_v2O
505 0 _aHans Nohl, Andrey Kozlov, Lars Gille, and Katrin Staniek: Endogenous oxidant-generating systems -- Peter Schroeder and Jean Krutmann: Environmental oxidative stress -- Helen Griffith: Chemical modifications of Biomolecules by oxidants -- Kelvin J.A. Davies: Broad spectrum of cellular reactions to oxidative stress -- Tilman Grune, Peter Schroeder, and Hans K. Biesalski: Low-molecular weight antioxidants -- Juan Sastre, Federico Pallardo, and Jose Vina: The glutathione system -- Grzegorz Bartosz: Superoxide dismutases and catalase -- Bente Riis, Henrik Poulsen: DNA-repair mechanisms -- Diana Poppek and Tilman Grune: Protein repair and degradation -- L.-O. Klotz: Metabolic regulation and gene expression in response to oxidative stress -- Enrique Cadenas and Alberto Boveris: Mitochondrial free radical production, antioxidant defenses and cell signaling.
520 _aOxidative stress is one of the major symptoms accompanying physiological functions and numerous diseases. Oxidants and free radicals are connected with diseases such as cancer, diabetes, infectious, cardiovascular and neurodegenerative diseases and also in the aging process itself. Therefore, comprehensive knowledge of the underlying mechanisms of oxidant and free radical production and the defence against this permanent threat to cells is important for the understanding of many physiological and pathophysiological processes. This book overviews the basic mechanisms of oxidant formation and antioxidant defences. In addition, the formation of oxidants and their detoxification, the damage of macromolecules and the major repair and removal systems will be highlighted.
650 0 _aMedicine.
650 0 _aPharmacology.
650 0 _aOccupational medicine.
650 0 _aPathology.
650 0 _aEcology.
650 0 _aGeoecology.
650 0 _aEnvironmental geology.
650 0 _aEcotoxicology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aPathology.
650 2 4 _aEcotoxicology.
650 2 4 _aGeoecology/Natural Processes.
650 2 4 _aOccupational Medicine/Industrial Medicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aEcology.
700 1 _aGrune, Tilman.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540224235
830 0 _aThe Handbook of Environmental Chemistry,
_x1433-6855 ;
_v2O
856 4 0 _uhttp://dx.doi.org/10.1007/b98750
912 _aZDB-2-EES
950 _aEarth and Environmental Science (Springer-11646)
999 _c504469
_d504469