000 03614nam a22004815i 4500
001 978-4-431-73884-8
003 DE-He213
005 20161121230812.0
007 cr nn 008mamaa
008 100301s2008 ja | s |||| 0|eng d
020 _a9784431738848
_9978-4-431-73884-8
024 7 _a10.1007/978-4-431-73884-8
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aHow the Immune System Recognizes Self and Nonself
_h[electronic resource] :
_bImmunoreceptors and Their Signaling /
_cedited by Daisuke Kitamura.
264 1 _aTokyo :
_bSpringer Japan,
_c2008.
300 _aXVIII, 251 p. 6 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aRecognition of Pathogens: Toll-Like Receptors -- Strategies of Natural Killer (NK) Cell Recognition and Their Roles in Tumor Immunosurveillance -- Recent Progress on Paired Immunoglobulin-Like Receptors -- Self-nonself Recognition through B-Cell Antigen Receptor -- How Do T Cells Discriminate Self from Nonself? -- Fc Receptors -- Self and Nonself Recognition by Coreceptors on B Lymphocytes: Regulation of B Lymphocytes by CD19, CD21, CD22, and CD72 -- Co-Receptors in the Positive and Negative Regulation of T-Cell Immunity.
520 _aHow do you discriminate yourself from other people? This question must sound odd to you since you easily recognize others at a glance and, without any effort, would not mistake them for yourself. However, it is not always easy for some people to discriminate themselves from others. For example, patients with schi- phrenia often talk with “others” living inside themselves. Thus it is likely that n- mally your brain actively recognizes and remembers the information belonging to yourself and discriminates it from the information provided by others, although you are not conscious of it. This brain function must have been particularly important for most animals to protect their lives from enemies and for species to survive through evolution. Similarly, higher organisms have also acquired their immune system through evolution that discriminates nonself pathogens and self-body to protect their lives from pathogens such as bacteria or viruses. The brain system may distinguish integrated images of self and nonself created from many inputs, such as vision, sound, smell, and others. The immune system recognizes and distinguishes a variety of structural features of self and nonself components. The latter actually include almost everything but self: for example, bacteria, viruses, toxins, pollens, chemicals, transplanted organs, and even tumor cells derived from self-tissue. To this end the immune system recruits different kinds of immune cells, such as B and T lymphocytes, natural killer (NK) cells, dendritic cells, and macrophages.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMolecular biology.
650 0 _aMedical biochemistry.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aMolecular Medicine.
650 2 4 _aMedical Biochemistry.
650 2 4 _aCell Biology.
700 1 _aKitamura, Daisuke.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9784431738831
856 4 0 _uhttp://dx.doi.org/10.1007/978-4-431-73884-8
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c504185
_d504185