000 02687nam a22004815i 4500
001 978-3-540-76330-7
003 DE-He213
005 20161121230810.0
007 cr nn 008mamaa
008 100301s2008 gw | s |||| 0|eng d
020 _a9783540763307
_9978-3-540-76330-7
024 7 _a10.1007/978-3-540-76330-7
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
245 1 0 _aSynaptic Plasticity and the Mechanism of Alzheimer's Disease
_h[electronic resource] /
_cedited by Dennis J. Selkoe, Antoine Triller, Yves Christen.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2008.
300 _aXII, 183 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aResearch and Perspectives in Alzheimer's Disease,
_x0945-6066
505 0 _aPermanence of the Synapse and Molecular Instability -- Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity -- Imaging of Experience-Dependent Structural Plasticity in the Mouse Neocortex in vivo -- Synapse Loss, Synaptic Plasticity and the Postsynaptic Density -- Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity -- Quantitative Neuropathology in Alzheimer’s Mouse Models -- Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease States -- Soluble Oligomers of the Amyloid ?-Protein: Impair Synaptic Plasticity and Behavior -- Why Alzheimer’s is a Disease of Memory: Synaptic Targeting by Pathogenic A? Oligomers (ADDLs) -- Synaptic Transmission Dynamically Modulates Interstitial Fluid Amyloid-? Levels -- A?-Induced Toxicity Mediated by Caspase Cleavage of the Amyloid Precursor Protein (APP) -- Long-Term Potentiation and A?: Targeting A? Species, Cellular Mechanisms and Putative Receptors -- Genes, Synapses and Autism Spectrum Disorders.
520 _a(will follow).
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aHuman Physiology.
700 1 _aSelkoe, Dennis J.
_eeditor.
700 1 _aTriller, Antoine.
_eeditor.
700 1 _aChristen, Yves.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540763291
830 0 _aResearch and Perspectives in Alzheimer's Disease,
_x0945-6066
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-540-76330-7
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c504127
_d504127