000			04073nam a22005055i 4500
001			978-3-540-75647-7
003			DE-He213
005			20161121230809.0
007			cr nn 008mamaa
008			100301s2008 gw | s |||| 0|eng d
020			_a9783540756477 _9978-3-540-75647-7
024	7		_a10.1007/978-3-540-75647-7 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
245	1	0	_aHumanized Mice _h[electronic resource] / _cedited by Tatsuji Nomura, Takeshi Watanabe, Sonoko Habu.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_aXIII, 199 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v324
505	0		_aBasic Concept of Development and Practical Application of Animal Models for Human Diseases -- Humanized SCID Mouse Models for Biomedical Research -- NOD/Shi-scid IL2r?null (NOG) Mice More Appropriate for Humanized Mouse Models -- Humanizing Bone Marrow in Immune-Deficient Mice -- The Differentiative and Regenerative Properties of Human Hematopoietic Stem/Progenitor cells in NOD-SCID/IL2r?null Mice -- Antigen-Specific Antibody Production of Human B Cells in NOG Mice Reconstituted with the Human Immune System -- Humanized Immune System (HIS) Mice as a Tool to Study Human NK Cell Development -- Human T Cell Development and HIV Infection in Human Hemato-Lymphoid System Mice -- Humanized Mice for Human Retrovirus Infection -- Functional and Phenotypic Characterization of the Humanized BLT Mouse Model -- Novel Metastasis Models of Human Cancer in NOG Mice -- In Vivo Imaging in Humanized Mice.
520			_aThe term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aHuman physiology.
650		0	_aImmunology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aHuman Genetics.
650	2	4	_aHuman Physiology.
700	1		_aNomura, Tatsuji. _eeditor.
700	1		_aWatanabe, Takeshi. _eeditor.
700	1		_aHabu, Sonoko. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540756460
830		0	_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v324
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-75647-7
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c504121 _d504121