000			03990nam a22004935i 4500
001			978-3-540-74966-0
003			DE-He213
005			20161121230809.0
007			cr nn 008mamaa
008			100301s2008 gw | s |||| 0|eng d
020			_a9783540749660 _9978-3-540-74966-0
024	7		_a10.1007/978-3-540-74966-0 _2doi
050		4	_aRC346-429.2
072		7	_aMJN _2bicssc
072		7	_aMED056000 _2bisacsh
082	0	4	_a616.8 _223
245	1	0	_aRetrotransposition, Diversity and the Brain _h[electronic resource] / _cedited by Fred H. Gage, Yves Christen.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_aXII, 123 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aResearch and Perspectives in Neurosciences, _x1861-2253
505	0		_aTelomeres and Telomerase in Human Health and Disease -- Molecular and Circuit Mechanisms for Hippocampal Learning -- Retrotransposons – Natural and Synthetic -- Ancient Retrotransposons as Possible Remnants of the Primitive RNPWorld -- Human Diversity and L1 Retrotransposon Biology: Creation of New Genes and Individual Variation in Retrotransposition Potential -- From the “RNAWorld” to Brain Complexity: Generation of Diversity -- Endogenous Retroviruses and Human Neuropsychiatric Disorders -- Is Psychosis Due to Retroviral/Retrotransposon Integration Close to the Cerebral Dominance Gene? -- Microcephalies and DNA Repair.
520			_aRetroelements are ancient mobile DNA found in most organisms. Long dismissed as useless, selfish or "junk" DNA, they were thought to be mere intracellular parasites from our distant evolutionary past. Together with their mutant relatives, L1 sequences constitute almost 50% of the mammalian genome. L1s can retrotranspose in a defined window of the neuronal differentiation, changing the genetic information in single neurons in a "random" fashion, allowing the brain to develop in distinct different ways. Such strategy contributes to expand the number of functionally distinct neurons that could be produced from a given stem cell gene pool. This characteristic of variety and flexibility may contribute to the uniqueness of an individual brain, even between genetically identical twins. These mobile elements may be part of conserved core process responsible for evoking facilitated complex non-random phenotypical variation on which selection may act. A detailed understanding of the basic mechanisms of L1 activity may shed light on one possible mechanism for generating neural diversity. The book results from a fascinating and stimulating exchange of ideas at the interface of the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility. This meeting of leading geneticists, molecular biologists and neuroscientists was organized by the Fondation IPSEN. Its ambitious goal was to expand the current limits of research in neurobiology not only to the benefit of those interested in the cellular and molecular processes but also for the understanding of high-level cognitive functions and the understanding of complex mental diseases. The reader can judge how far the book achieves this.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aNeurosciences.
650		0	_aNeurology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aNeurology.
650	2	4	_aNeurosciences.
650	2	4	_aHuman Genetics.
700	1		_aGage, Fred H. _eeditor.
700	1		_aChristen, Yves. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540749653
830		0	_aResearch and Perspectives in Neurosciences, _x1861-2253
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-74966-0
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c504111 _d504111