000			04485nam a22005055i 4500
001			978-3-540-74806-9
003			DE-He213
005			20161121230809.0
007			cr nn 008mamaa
008			100301s2008 gw | s |||| 0|eng d
020			_a9783540748069 _9978-3-540-74806-9
024	7		_a10.1007/978-3-540-74806-9 _2doi
050		4	_aRM1-950
072		7	_aMMG _2bicssc
072		7	_aMED071000 _2bisacsh
082	0	4	_a615 _223
245	1	0	_aModern Anesthetics _h[electronic resource] / _cedited by Jürgen Schüttler, Helmut Schwilden.
246	3		_aWith contributions by numerous experts
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_aXVI, 498 p. 112 illus., 5 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aHandbook of Experimental Pharmacology, _x0171-2004 ; _v182
505	0		_aMolecular Mechanisms of Anesthetic Action -- The Site of Anesthetic Action -- Inhibitory Ligand-Gated Ion Channels as Substrates for General Anesthetic Actions -- Actions of Anesthetics on Excitatory Transmitter-Gated Channels -- Voltage-Gated Ion Channels -- G-Protein-Coupled Receptors -- Modern Inhalation Anesthetics -- Inhalation Anaesthesia: From Diethyl Ether to Xenon -- General Anesthetics and Long-Term Neurotoxicity -- Special Aspects of Pharmacokinetics of Inhalation Anesthesia -- Inhalational Anaesthetics and Cardioprotection -- Non-Immobilizing Inhalational Anesthetic-Like Compounds -- Modern Intravenous Anesthetics -- Propofol -- Pharmacokinetics and Pharmacodynamics of GPI 15715 or Fospropofol (Aquavan Injection) — A Water-Soluble Propofol Prodrug -- Etomidate and Other Non-Barbiturates -- Remifentanil and Other Opioids -- Ketamine -- Midazolam and Other Benzodiazepines -- Pharmacokinetics-Pharmacodynamics Based Administration of Anesthetics -- The Effect of Altered Physiological States on Intravenous Anesthetics -- Anesthetics Drug Pharmacodynamics -- Defining Depth of Anesthesia -- Target Controlled Anaesthetic Drug Dosing -- Advanced Technologies and Devices for Inhalational Anesthetic Drug Dosing -- Hypnotic and Opioid Anesthetic Drug Interactions on the CNS, Focus on Response Surface Modeling.
520			_aSome important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
650		0	_aMedicine.
650		0	_aPharmacology.
650		0	_aAnesthesiology.
650		0	_aEmergency medicine.
650	1	4	_aBiomedicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aAnesthesiology.
650	2	4	_aEmergency Medicine.
700	1		_aSchüttler, Jürgen. _eeditor.
700	1		_aSchwilden, Helmut. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540728139
830		0	_aHandbook of Experimental Pharmacology, _x0171-2004 ; _v182
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-74806-9
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c504107 _d504107