000			03318nam a22005535i 4500
001			978-3-540-73853-4
003			DE-He213
005			20161121230808.0
007			cr nn 008mamaa
008			100301s2008 gw | s |||| 0|eng d
020			_a9783540738534 _9978-3-540-73853-4
024	7		_a10.1007/978-3-540-73853-4 _2doi
050		4	_aRC109-216
072		7	_aMJCJ _2bicssc
072		7	_aMED022090 _2bisacsh
082	0	4	_a616.9 _223
245	1	0	_aControl of Biofilm Infections by Signal Manipulation _h[electronic resource] / _cedited by Naomi Balaban.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_aXVI, 175 p. 56 illus., 13 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringer Series on Biofilms, _x1863-9607 ; _v2
505	0		_aBacterial Cell-to-cell Communication (Quorum Sensing) -- Detection In Vitro of Quorum-Sensing Molecules and Their Inhibitors -- Quorum-Sensing Inhibitory Compounds -- Mathematical Modeling of Quorum-Sensing Control in Biofilms -- Animal Models Commonly Used to Study Quorum-Sensing Inhibitors -- In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs -- Quorum Sensing in Streptococci -- Ironing Out the Biofilm Problem:The Role of Iron in Biofilm Formation -- Clinical Wound Healing Using Signal Inhibitors.
520			_aThe medical miracle of antibiotics is being eroded by the emergence and spread of bacterial drug resistance. This is compounded by the fact that bacterial biofilms are believed to be a common cause of persistent infections, when because growing in biofilms, bacteria are protected from the host’s immune response and from antibiotics. In addition, biofilms may spawn systemic infections by sloughing of planktonic bacteria, leading to dissemination, bacteremia, sepsis, and death. The number of patients affected by and dying from what can be considered as a "biofilm disease" is higher than heart disease and cancer combined, making medical biofilms the biggest single disease that the healthcare system is facing today. This book describes the molecular mechanisms of cell-to-cell communication among bacterial cells in a biofilm, the development of antibiofilm inhibitors, like quorum-sensing inhibitors, and the use of biofilm inhibitors to prevent and treat bacterial infections in humans and other animals.
650		0	_aMedicine.
650		0	_aInfectious diseases.
650		0	_aProteomics.
650		0	_aBioinformatics.
650		0	_aCell biology.
650		0	_aMicrobiology.
650		0	_aBacteriology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aInfectious Diseases.
650	2	4	_aMicrobiology.
650	2	4	_aBacteriology.
650	2	4	_aCell Biology.
650	2	4	_aBioinformatics.
650	2	4	_aProteomics.
700	1		_aBalaban, Naomi. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540738527
830		0	_aSpringer Series on Biofilms, _x1863-9607 ; _v2
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-73853-4
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c504093 _d504093