000			03657nam a22005415i 4500
001			978-3-540-72602-9
003			DE-He213
005			20161121230807.0
007			cr nn 008mamaa
008			100301s2008 gw | s |||| 0|eng d
020			_a9783540726029 _9978-3-540-72602-9
024	7		_a10.1007/978-3-540-72602-9 _2doi
050		4	_aQP351-495
072		7	_aPSAN _2bicssc
072		7	_aSCI070000 _2bisacsh
072		7	_aMED057000 _2bisacsh
082	0	4	_a573.8 _223
245	1	0	_aInhibitory Regulation of Excitatory Neurotransmission _h[electronic resource] / _cedited by Mark G. Darlison.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_aXVI, 248 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aResults and Problems in Cell Differentiation, _x0080-1844 ; _v44
505	0		_aRegulation of Excitation by GABAA Receptor Internalization -- Regulation of Excitability by Extrasynaptic GABAA Receptors -- GABAC Receptors in Retina and Brain -- Presynaptic Ionotropic GABA Receptors -- The Role of GABAB Receptors in the Regulation of Excitatory Neurotransmission -- GABAergic Control of CA3-driven Network Events in the Developing Hippocampus -- Regulation of Excitation by Glycine Receptors -- Regulation of Excitability by Potassium Channels -- Modulation of Excitation by Metabotropic Glutamate Receptors -- Presynaptic Inhibition of Glutamate Release by Neuropeptides: Use-Dependent Synaptic Modification -- Regulation of Excitation by GABA Neurotransmission: Focus on Metabolism and Transport -- Human Disorders Caused by the Disruption of the Regulation of Excitatory Neurotransmission.
520			_aWithin the central and peripheral nervous systems of animals, including man, inhibition is crucial to counterbalance excitatory neurotransmission, which is predominantly mediated by glutamate and its receptors. Although, particularly in brain, much of this inhibition is provided by classical post-synaptic GABAA receptors, many other proteins and mechanisms regulate excitation. These exist both to "fine tune" neurotransmission and to prevent overexcitation that could lead to conditions such as epilepsy and excitotoxicity, which can result in cell death. This book reviews aspects of GABAA receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABAC receptors, G-protein coupled receptors (specifically, GABAB receptors, metabotropic glutamate receptors and neuropeptide receptors), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed.
650		0	_aLife sciences.
650		0	_aNeurosciences.
650		0	_aBiochemistry.
650		0	_aCell biology.
650		0	_aAnimal physiology.
650		0	_aNeurobiology.
650	1	4	_aLife Sciences.
650	2	4	_aNeurobiology.
650	2	4	_aCell Biology.
650	2	4	_aNeurosciences.
650	2	4	_aAnimal Physiology.
650	2	4	_aBiochemistry, general.
700	1		_aDarlison, Mark G. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540726012
830		0	_aResults and Problems in Cell Differentiation, _x0080-1844 ; _v44
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-72602-9
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c504072 _d504072