000			03328nam a22004815i 4500
001			978-3-540-69161-7
003			DE-He213
005			20161121230806.0
007			cr nn 008mamaa
008			100301s2007 gw | s |||| 0|eng d
020			_a9783540691617 _9978-3-540-69161-7
024	7		_a10.1007/978-3-540-69161-7 _2doi
050		4	_aQH491
072		7	_aPSC _2bicssc
072		7	_aSCI072000 _2bisacsh
082	0	4	_a571.8 _223
245	1	0	_aAsymmetric Cell Division _h[electronic resource] / _cedited by Alvaro Macieira-Coelho.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2007.
300			_aXII, 248 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProgress in Molecular and Subcellular Biology, _x0079-6484 ; _v45
505	0		_aAsymmetric Cell Division in Plant Development -- Asymmetric Cell Division – How Flowering Plant Cells Get Their Unique Identity -- Symmetry Breaking in Stem Cells of the Basal Metazoan Hydra -- Asymmetric Cell Divisions in the Early Embryo of the Leech Helobdella robusta -- Asymmetric Divisions of Germline Cells -- Asymmetric Cell Division During Brain Morphogenesis -- Generating Asymmetry: With and Without Self-Renewal -- Cell Commitment by Asymmetric Division and Immune System Involvement -- Asymmetric Stem Cell Division in Development and Cancer -- Asymmetric Distribution of DNA Between Daughter Cells with Final Symmetry Breaking During Aging of Human Fibroblasts.
520			_aCell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
650		0	_aLife sciences.
650		0	_aCancer research.
650		0	_aCell biology.
650		0	_aDevelopmental biology.
650	1	4	_aLife Sciences.
650	2	4	_aDevelopmental Biology.
650	2	4	_aCell Biology.
650	2	4	_aCancer Research.
700	1		_aMacieira-Coelho, Alvaro. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540691600
830		0	_aProgress in Molecular and Subcellular Biology, _x0079-6484 ; _v45
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-69161-7
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c504041 _d504041