000 02502nam a22004575i 4500
001 978-3-540-37107-6
003 DE-He213
005 20161121230804.0
007 cr nn 008mamaa
008 100301s2007 gw | s |||| 0|eng d
020 _a9783540371076
_9978-3-540-37107-6
024 7 _a10.1007/978-3-540-37107-6
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aBritsch, Stefan.
_eauthor.
245 1 4 _aThe Neuregulin-I/ErbB Signaling System in Development and Disease
_h[electronic resource] /
_cby Stefan Britsch.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2007.
300 _aXI, 70 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Anatomy Embryology and Cell Biology,
_x0301-5556 ;
_v190
505 0 _aIntroduction – Molecular control of development -- Biology of the Neuregulin/ErbB signaling network -- Neuregulins and their receptors -- Developmental functions of the Neuregulin-1/ErbB signalling pathway -- Interacting molecules – the Sox10/ErbB connection -- NRG-1/ErbB signals and disease -- Abbreviations -- References -- Subject index.
520 _aNeuregulins are EGF-like growth and differentiation factors that interact with tyrosine kinase receptors of the ErbB family. this signailing system has a wide range of functions during development of the nervous system, the heart, and the mammary gland. Furthermore, Neuregulin signals are also involved in the development of human diseases including breast cancer, heart disease and the pathogenesis of schizophrenia. This monograph reviews the biology of Neuregulins and their receptors and summarizes recent research, which has established crucial functions of this signaling system during development and disease. .
650 0 _aMedicine.
650 0 _aMolecular biology.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540371052
830 0 _aAdvances in Anatomy Embryology and Cell Biology,
_x0301-5556 ;
_v190
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-540-37107-6
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c504001
_d504001