000			03598nam a22005175i 4500
001			978-3-540-31339-7
003			DE-He213
005			20161121230804.0
007			cr nn 008mamaa
008			100301s2007 gw | s |||| 0|eng d
020			_a9783540313397 _9978-3-540-31339-7
024	7		_a10.1007/978-3-540-31339-7 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
245	1	0	_aSystems Biology _h[electronic resource] : _bApplications and Perspectives / _cedited by P. Bringmann, E. C. Butcher, G. Parry, B. Weiss.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2007.
300			_aXIII, 177 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aErnst Schering Research Foundation Workshop, _x0947-6075 ; _v61
505	0		_aRNAi Applications in Target Validation -- Does the Serum Peptidome Reveal Hemostatic Dysregulation? -- Systems Biology: New Paradigms for Cell Biology and Drug Design -- The Theory of Biological Robustness and Its Implication in Cancer -- Network Genomics -- A Plea for More Theory in Molecular Biology -- Applying a Causal Framework to System Modeling -- Can Cell Systems Biology Rescue Drug Discovery?.
520			_aSystems biology has emerged as a highly interdisciplinary ?eld that has created broad enthusiasm in the scienti?c community. Systems biology is in vogue because of its potential to revolutionize not only biology but also medicine. Developments are anticipated that will change how we think about disease and how we approach therapeutic intervention. Perhaps the boldest vision of this future is presented by Dr. Leroy Hood, President of the Institute for Systems Biology in Seattle. He has been a protagonist and the main driving force of the underlying concept. - cording to Dr. Hood, systems biology will make possible a new era of medical care comprising predictive, preventive, personalized and part- ipatory (P4) medicine. While this vision appears futuristic, it has enticed both academic scienti?c communities and pharmaceutical industry R&D organizations. Systems biology ultimately attempts to understand biological s- tems at the molecular level. Examples of such systems are subcellular regulatory circuits with all their components, cells, organs, as well as - tire organisms. Over the past decade, technologies have been developed that enable systems-level interrogations, e.g., gene expression pro?ling, proteomics, and metabonomics, to name a few. Scientists have used such platforms to accumulate a tremendous amount of data. Although we have learned a great deal by collecting such detailed information, it seems our understanding has not similarly increased.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aEndocrinology.
650		0	_aCell biology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aCell Biology.
650	2	4	_aEndocrinology.
700	1		_aBringmann, P. _eeditor.
700	1		_aButcher, E. C. _eeditor.
700	1		_aParry, G. _eeditor.
700	1		_aWeiss, B. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540313380
830		0	_aErnst Schering Research Foundation Workshop, _x0947-6075 ; _v61
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-31339-7
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c503977 _d503977