000			03891nam a22004575i 4500
001			978-1-59745-176-5
003			DE-He213
005			20161121230803.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9781597451765 _9978-1-59745-176-5
024	7		_a10.1007/978-1-59745-176-5 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
245	1	4	_aThe Genetics of Male Infertility _h[electronic resource] / _cedited by Douglas T. Carrell.
264		1	_aTotowa, NJ : _bHumana Press, _c2007.
300			_aXVI, 337 p. 47 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aMethods and Tools for the Study -- The Genetics of Male Infertility in the Era of Genomics -- The Use of cDNA Libraries to Demonstrate a Linkage Between Transcription and Translation in Male Germ Cells -- Considerations When Using Array Technologies for Male Factor Assessment -- Microarray Analysis of a Large Number of Single-Nucleotide Polymorphisms in Individual Human Spermatozoa -- Physiological and Proteomic Approaches to Understanding Human Sperm Function -- Genetics of Idiopathic Male Infertility -- Meiosis and Errors of Meiosis -- The Immunocytogenetics of Human Male Meiosis -- The Clinical Relevance of Sperm Aneuploidy -- DNA Repair Genes and Genomic Instability in Severe Male Factor Infertility -- The Y Chromosome, Development Spermatogenesis, and Sperm Maturation -- Germ Cell-Specific Genes and Posttranscriptional Regulation in the Testis -- The Genetics of Cryptorchidism -- The Chromatoid Body and microRNA Pathways in Male Germ Cells -- Sperm Maturation in the Epididymis -- Clinical Applications of the Study of the Genetics of Male Infertility -- The Structure of the Y Chromosome and Its Role in Male Infertility -- Y Chromosome Microdeletions and Haplotypes -- The Genetics of Male Infertility -- The Future of the Diagnosis of Male (In) Fertility -- Polymorphisms and Male Infertility -- The Genetics of Abnormal Protamine Expression -- Chromatin Damage and Male Infertility -- Clinical Evaluation of the Genetics of Male Infertility.
520			_aInfertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms. Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aUrology.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aUrology.
700	1		_aCarrell, Douglas T. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588298638
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59745-176-5
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c503955 _d503955