000 04434nam a22005055i 4500
001 978-1-4020-8831-5
003 DE-He213
005 20161121230802.0
007 cr nn 008mamaa
008 100301s2008 ne | s |||| 0|eng d
020 _a9781402088315
_9978-1-4020-8831-5
024 7 _a10.1007/978-1-4020-8831-5
_2doi
050 4 _aQP34-38
072 7 _aMFG
_2bicssc
072 7 _aMED075000
_2bisacsh
082 0 4 _a612
_223
245 1 0 _aLipids in Health and Disease
_h[electronic resource] /
_cedited by Peter J. Quinn, Xiaoyuan Wang.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2008.
300 _aXXII, 598 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v49
505 0 _aFatty Acids -- Transcriptional Regulation of Hepatic Fatty Acid Metabolism -- Modulation of Protein Function by Isoketals and Levuglandins -- Signalling Pathways Controlling Fatty Acid Desaturation -- Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System -- Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids -- Eicosanoids in Tumor Progression and Metastasis -- Fatty Acid Synthase Activity in Tumor Cells -- Phospholipids -- Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders -- Altered Lipid Metabolism in Brain Injury and Disorders -- Lysophospholipid Activation of G Protein-Coupled Receptors -- Phospholipid-Mediated Signaling and Heart Disease -- The Role of Phospholipid Oxidation Products in Inflammatory and Autoimmune Diseases -- Mediation of Apoptosis by Oxidized Phospholipids -- Sphingolipids -- Regulation of lipid metabolism by sphingolipids -- Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis -- Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics -- Glycosphingolipid Disorders of the Brain -- Role of Neutral Sphingomyelinases in Aging and Inflammation -- Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets -- Ceramide-Enriched Membrane Domains in Infectious Biology and Development -- Lipidomics -- MALDI-TOF MS Analysis of Lipids from Cells, Tissues and Body Fluids -- Lipidomics in diagnosis of lipidoses.
520 _aLipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aBiochemistry.
650 0 _aLipids.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Physiology.
650 2 4 _aBiomedicine general.
650 2 4 _aBiochemistry, general.
650 2 4 _aLipidology.
700 1 _aQuinn, Peter J.
_eeditor.
700 1 _aWang, Xiaoyuan.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402088308
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v49
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-8831-5
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503942
_d503942