000 04178nam a22004695i 4500
001 978-1-4020-8399-0
003 DE-He213
005 20161121230801.0
007 cr nn 008mamaa
008 100301s2008 ne | s |||| 0|eng d
020 _a9781402083990
_9978-1-4020-8399-0
024 7 _a10.1007/978-1-4020-8399-0
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
245 1 0 _aOxidants in Biology
_h[electronic resource] :
_bA Question of Balance /
_cedited by Giuseppe Valacchi, Paul A. Davis.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2008.
300 _aVIII, 328 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aOld Players -- Hydrogen Peroxide: The Good, The Bad, and The Ugly -- Peroxynitrite: A Key Molecule in Skin Tissue Response to Different Types of Stress -- Cellular and Environmental Electrophiles: Balancing Redox Signaling, Inflammation, and Cell Death Pathways -- The Role of Reactive Nitrogen Species (RNS) in the Activation of Nuclear Factor Kappa B (NFkB) and Its Implications for Biological Systems: The Question of Balance -- Neutrophil-Derived Oxidants as Modulators of Polyunsaturated Fatty Acid Metabolism -- Fatty Acids in the Modulation of Reactive Oxygen Species Balance in Cancer -- The Question of Balance: The Interaction Between Blood and Ozone -- Iron and Erythrocytes: Physiological and Pathophysiological Aspects -- The Adventures of Superoxide Dismutase in Health and Disease: Superoxide in the Balance -- Glutathione Metabolism: Favorable Versus Unfavorable Effects -- Dual Roles of Oxidative Stress in the Lungs -- Antioxidants: How They Work -- New Players -- The Role of DUOX Isozymes in the Respiratory Tract Epithelium -- Hypertension, Diabetes, Oxidative Stress, and Cardiovascular Remodeling: Making the Connection with p66shc -- A Role of BRCA1-Associated Protein BARD1 in Oxidative Stress Response and Signaling and Proliferation Control -- Postprandial Events as a Trigger for Redox Unbalance: Role of Dietary Lipid Hydroperoxides and Antioxidants -- F2-Isoprostanes: Markers and Mediators of an Imbalanced Redox Status in the Liver.
520 _aOxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.
650 0 _aMedicine.
650 0 _aPharmacology.
650 0 _aChemistry.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aChemistry/Food Science, general.
650 2 4 _aCell Biology.
700 1 _aValacchi, Giuseppe.
_eeditor.
700 1 _aDavis, Paul A.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402083983
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-8399-0
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503910
_d503910