000 05462nam a22005655i 4500
001 978-1-4020-8231-3
003 DE-He213
005 20161121230800.0
007 cr nn 008mamaa
008 100301s2008 ne | s |||| 0|eng d
020 _a9781402082313
_9978-1-4020-8231-3
024 7 _a10.1007/978-1-4020-8231-3
_2doi
050 4 _aRC346-429.2
072 7 _aMJN
_2bicssc
072 7 _aMED056000
_2bisacsh
082 0 4 _a616.8
_223
245 1 0 _aHeat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
_h[electronic resource] /
_cedited by Alexzander A.A. Asea, Ian R. Brown.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2008.
300 _aXVI, 373 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHeat Shock Proteins ;
_v3
505 0 _aHeat Shock Proteins and Neurodegenerative Diseases -- Chaperones and Polyglutamine Expansion Disorders -- Heat Shock Proteins, Unfolded Protein Response Chaperones and Alzheimer’s Disease -- Cellular and Molecular Mechanisms Underlying Parkinson’s Disease: The Role of Molecular Chaperones -- Heat Shock Proteins as Therapeutic Targets in Amyotrophic Lateral Sclerosis -- The Role of Chaperones and Co-Chaperones in Retinal Degenerative Diseases -- Neuroprotective Features Of Hsp90 Inhibitors Exhibiting Anti-Inflammatory Actions: Implications For Multiple Sclerosis -- Role of HspB1 and HspB8 in Hereditary Peripheral Neuropathies: Beyond the Chaperone Function -- Heat Shock Proteins and Neuroprotection -- Heat Shock Proteins Hsp70 and Hsp27 and Neural Cellular Protection -- Molecular Chaperones and Protection in Animal and Cellular Models of Ischemic Stroke -- Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stress Response in Motor Neurons -- Use of Viral Gene Delivery Systems to Investigate the Neuroprotective Roles of Hsp70 and Hsp40 Proteins -- Heat Shock Proteins at the Synapse: Implications for Functional Protection of the Nervous System -- Extracellular Heat Shock Proteins and The Nervous System -- Release of Heat Shock Proteins and their Effects When in the Extracellular Space in the Nervous System -- Silencing of Metastasis-associated Gene 1 (Mta1) Stimulates Hsp70 Cellular Release and Neurite extension in Neuroblastoma Cells -- Extracellular Chaperones and Amyloids -- Aging, Control Of Life Span and Expression Of Heat Shock Proteins -- Neural Expression Of Small Heat Shock Proteins Influences Longevity And Resistance To Oxidative Stress -- Mechanistic Links Between Aging and Aggregation-Mediated Proteotoxicity: Role of HSF-1 and DAF-16 -- Protein Quality Control and Heat Shock Gene Expression in the Nervous System -- Serum Hsp70 Level as a Biomarker of Exceptional Longevity -- Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection.
520 _aWith the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aLaboratory medicine.
650 0 _aMolecular biology.
650 0 _aNeurosciences.
650 0 _aPharmacology.
650 0 _aNeurology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aNeurology.
650 2 4 _aNeurosciences.
650 2 4 _aMolecular Medicine.
650 2 4 _aLaboratory Medicine.
650 2 4 _aHuman Physiology.
650 2 4 _aPharmacology/Toxicology.
700 1 _aAsea, Alexzander A.A.
_eeditor.
700 1 _aBrown, Ian R.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402082306
830 0 _aHeat Shock Proteins ;
_v3
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-8231-3
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503892
_d503892