000 | 03816nam a22005415i 4500 | ||
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001 | 978-1-4020-6554-5 | ||
003 | DE-He213 | ||
005 | 20161121230758.0 | ||
007 | cr nn 008mamaa | ||
008 | 100301s2008 ne | s |||| 0|eng d | ||
020 |
_a9781402065545 _9978-1-4020-6554-5 |
||
024 | 7 |
_a10.1007/978-1-4020-6554-5 _2doi |
|
050 | 4 | _aRC261-271 | |
072 | 7 |
_aMJCL _2bicssc |
|
072 | 7 |
_aMED062000 _2bisacsh |
|
082 | 0 | 4 |
_a614.5999 _223 |
100 | 1 |
_aKhosravi-Far, Roya. _eauthor. |
|
245 | 1 | 0 |
_aProgrammed Cell Death in Cancer Progression and Therapy _h[electronic resource] / _cby Roya Khosravi-Far, Eileen White. |
264 | 1 |
_aDordrecht : _bSpringer Netherlands, _c2008. |
|
300 |
_aXIV, 356 p. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v615 |
|
505 | 0 | _aCell Death: History and Future -- Caspase Mechanisms -- The Mitochondrial Death Pathway -- Apoptotic Pathways in Tumor Progression and Therapy -- Therapeutic Targeting of Death Pathways in Cancer: Mechanisms for Activating Cell Death in Cancer Cells -- Overcoming Resistance to Apoptosis in Cancer Therapy -- Trail Receptors: Targets for Cancer Therapy -- Rational Design of Therapeutics Targeting the BCL-2 Family: Are Some Cancer Cells Primed for Death but Waiting for a Final Push? -- Autophagy and Tumor Suppression: Recent Advances in Understanding the Link between Autophagic Cell Death Pathways and Tumor Development -- Regulation of Programmed Cell Death by the P53 Pathway -- Regulation of Programmed Cell Death by NF-?B and its Role in Tumorigenesis and Therapy -- Targeting Proteasomes as Therapy in Multiple Myeloma -- Histone Deacetylase Inhibitors: Mechanisms and Clinical Significance in Cancer: HDAC Inhibitor-Induced Apoptosis -- RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches -- Cancer Stem Cells and Impaired Apoptosis. | |
520 | _aProgrammed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has risen dramatically. With this book, we give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents. Additionally, this book will be a important educational source for PhD students specializing in cell biology, immunology and MD students interested in Oncology and Cancer Therapeutics. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aCancer research. | |
650 | 0 | _aImmunology. | |
650 | 0 | _aMolecular biology. | |
650 | 0 | _aOncology. | |
650 | 0 | _aCell biology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
650 | 2 | 4 | _aCell Biology. |
650 | 2 | 4 | _aMolecular Medicine. |
650 | 2 | 4 | _aImmunology. |
650 | 2 | 4 | _aOncology. |
700 | 1 |
_aWhite, Eileen. _eauthor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781402065538 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v615 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4020-6554-5 |
912 | _aZDB-2-SBL | ||
950 | _aBiomedical and Life Sciences (Springer-11642) | ||
999 |
_c503854 _d503854 |