000			03019nam a22004935i 4500
001			978-1-4020-6311-4
003			DE-He213
005			20161121230757.0
007			cr nn 008mamaa
008			100301s2007 ne | s |||| 0|eng d
020			_a9781402063114 _9978-1-4020-6311-4
024	7		_a10.1007/978-1-4020-6311-4 _2doi
050		4	_aRB1-214
072		7	_aMMF _2bicssc
072		7	_aMED067000 _2bisacsh
082	0	4	_a616.07 _223
245	1	0	_aIntramembrane-Cleaving Proteases (I-CLiPs) _h[electronic resource] / _cedited by Nigel M. Hooper, Uwe Lendeckel.
264		1	_aDordrecht : _bSpringer Netherlands, _c2007.
300			_aIX, 142 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProteases in Biology and Disease ; _v6
505	0		_aThe Site-2 Protease at Ten -- Signal Peptide Peptidases -- GXGD-Type Intramembrane Proteases -- Rhomboid Intramembrane Serine Proteases -- Proteases of the Rhomboid Family in the Yeast Saccharomyces Cerevisiae -- ?-Secretase And Alzheimer’S Disease -- ?-Secretase Mediated Proteolysis: At the Cutting Edge of Notch Signaling.
520			_aIn recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.
650		0	_aMedicine.
650		0	_aNeurosciences.
650		0	_aPathology.
650		0	_aCell biology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aPathology.
650	2	4	_aNeurosciences.
650	2	4	_aCell Biology.
700	1		_aHooper, Nigel M. _eeditor.
700	1		_aLendeckel, Uwe. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402063107
830		0	_aProteases in Biology and Disease ; _v6
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4020-6311-4
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c503836 _d503836