000 04238nam a22004695i 4500
001 978-1-4020-5963-6
003 DE-He213
005 20161121230756.0
007 cr nn 008mamaa
008 100301s2007 ne | s |||| 0|eng d
020 _a9781402059636
_9978-1-4020-5963-6
024 7 _a10.1007/978-1-4020-5963-6
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aYeast as a Tool in Cancer Research
_h[electronic resource] /
_cedited by John L. Nitiss, Joseph Heitman.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2007.
300 _aXVI, 433 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aFrom DNA Replication to Genome Instability in Schizosaccharomyces Pombe: Pathways to Cancer -- Dissecting Layers of Mitotic Regulation Essential for Maintaining Genomic Stability -- Yeast as a Tool in Cancer Research: Nuclear Trafficking -- Studies of Protein Farnesylation in Yeast -- From Bread to Bedside: What Budding Yeast has Taught us about the Immortalization of Cancer Cells -- HSP90 Co-Chaperones in Saccharomyces Cerevisiae -- Yeast as a Model System for Studying Cell Cycle Checkpoints -- Metabolism and Function of Sphingolipids in Saccharomyces Cerevisiae: Relevance to Cancer Research -- Exploring and Restoring the p53 Pathway Using the p53 Dissociator Assay in Yeast -- Functional Analysis of the Human p53 Tumor Suppressor and its Mutants Using Yeast -- ABC Transporters in Yeast – Drug Resistance and Stress Response in a Nutshell -- The FHCRC/NCI Yeast Anticancer Drug Screen -- Yeast as a Model to Study the Immunosuppressive and Chemotherapeutic Drug Rapamycin -- Use of Yeast as a Model System for Identifying and Studying Anticancer Drugs -- Genetic Analysis of Cisplatin Resistance in Yeast and Mammals -- Using Yeast Tools to Dissect the Action of Anticancer Drugs: Mechanisms of Enzyme Inhibition and Cell Killing by Agents Targeting DNA Topoisomerases.
520 _aLeland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein–protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind’s most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aPharmacology.
650 0 _aBiotechnology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aBiotechnology.
700 1 _aNitiss, John L.
_eeditor.
700 1 _aHeitman, Joseph.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402059629
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-5963-6
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503796
_d503796