| 000 | 02980nam a22004575i 4500 | ||
|---|---|---|---|
| 001 | 978-1-4020-5847-9 | ||
| 003 | DE-He213 | ||
| 005 | 20161121230755.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s2007 ne | s |||| 0|eng d | ||
| 020 |
_a9781402058479 _9978-1-4020-5847-9 |
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| 024 | 7 |
_a10.1007/978-1-4020-5847-9 _2doi |
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| 050 | 4 | _aRC261-271 | |
| 072 | 7 |
_aMJCL _2bicssc |
|
| 072 | 7 |
_aMED062000 _2bisacsh |
|
| 082 | 0 | 4 |
_a614.5999 _223 |
| 245 | 1 | 0 |
_aMetastasis of Prostate Cancer _h[electronic resource] / _cedited by Richard J. Ablin, Malcolm D. Mason. |
| 264 | 1 |
_aDordrecht : _bSpringer Netherlands, _c2007. |
|
| 300 |
_aXIV, 407 p. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aCancer Metastasis – Biology and Treatment, _x1568-2102 ; _v10 |
|
| 520 | _aWithout metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aCancer research. | |
| 650 | 0 | _aOncology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aCancer Research. |
| 650 | 2 | 4 | _aOncology. |
| 700 | 1 |
_aAblin, Richard J. _eeditor. |
|
| 700 | 1 |
_aMason, Malcolm D. _eeditor. |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781402058462 |
| 830 | 0 |
_aCancer Metastasis – Biology and Treatment, _x1568-2102 ; _v10 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4020-5847-9 |
| 912 | _aZDB-2-SBL | ||
| 950 | _aBiomedical and Life Sciences (Springer-11642) | ||
| 999 |
_c503788 _d503788 |
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