000 03462nam a22005775i 4500
001 978-1-4020-5252-1
003 DE-He213
005 20161121230754.0
007 cr nn 008mamaa
008 100301s2007 ne | s |||| 0|eng d
020 _a9781402052521
_9978-1-4020-5252-1
024 7 _a10.1007/1-4020-5252-9
_2doi
050 4 _aQD431-431.7
072 7 _aPSBC
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572.6
_223
245 1 0 _aSystems Biology
_h[electronic resource] /
_cedited by Mohamed Al-Rubeai, Martin Fussenegger.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2007.
300 _aVIII, 424 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCell Engineering,
_x1389-6946 ;
_v5
505 0 _aStructural Genomics -- RNA Interference in Haematopoietic and Leukaemic Cells -- Genomics and Proteomics of Chinese Hamster Ovary (CHO) Cells -- The Unfolded Protein Response -- Engineering of Cell Proliferation Via Myc Modulation -- The Molecular Response(s) During Cellular Adaptation to, and Recovery from, Sub-Physiological Temperatures -- Molecular Response to Osmotic Shock -- Metabolomics -- Metabolic Flux Analysis of Mammalian Cells -- Metabolic Engineering -- Chemical Organisation Theory -- Prokaryotic Systems Biology.
520 _aA comprehensive guide to the revolutionary area of systems biology and its application in cell culture engineering, this volume presents an overall picture of the current topics central to structural and functional genomics, proteomics, metabolomics and bioinformatics, including such hot topics as RNAi, metabolic engineering and unfolded protein response. It includes reviews of the cellular response of environmental modulation such as low temperature and osmolarity, critical assessments of the applications of metabolomics and fluxomics approaches, examination of the utility of modulation of key genes and a presentation of a theory of chemical organisation which provides a new view of the system's structure. The clearly written chapters by experts in the field describe methods applicable to investigating the unique facets of cell culture. The book should be of interest to all those working in cell culture development and drug discovery in pharmaceutical and biotechnology companies as well as in academic institutions. It provides an invaluable resource for students and researchers in biotechnology, cell culture, genomics and bioinformatics.
650 0 _aLife sciences.
650 0 _aProteomics.
650 0 _aProteins.
650 0 _aBioinformatics.
650 0 _aCell biology.
650 0 _aMicrobiology.
650 0 _aMicrobial genetics.
650 0 _aMicrobial genomics.
650 1 4 _aLife Sciences.
650 2 4 _aProteomics.
650 2 4 _aProtein Science.
650 2 4 _aMicrobiology.
650 2 4 _aBioinformatics.
650 2 4 _aCell Biology.
650 2 4 _aMicrobial Genetics and Genomics.
700 1 _aAl-Rubeai, Mohamed.
_eeditor.
700 1 _aFussenegger, Martin.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402052514
830 0 _aCell Engineering,
_x1389-6946 ;
_v5
856 4 0 _uhttp://dx.doi.org/10.1007/1-4020-5252-9
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503760
_d503760