000			03615nam a22004695i 4500
001			978-0-387-78887-6
003			DE-He213
005			20161121230753.0
007			cr nn 008mamaa
008			100301s2008 xxu| s |||| 0|eng d
020			_a9780387788876 _9978-0-387-78887-6
024	7		_a10.1007/978-0-387-78887-6 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
245	1	0	_aCyclin Dependent Kinase 5 (Cdk5) _h[electronic resource] / _cedited by Li-Huei Tsai, Nancy Y. Ip.
264		1	_aBoston, MA : _bSpringer US : _bImprint: Springer, _c2008.
300			_aXVI, 313 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aCdk5/p35 Regulates Neuronal Migration -- CRMP Family Protein: Novel Targets for Cdk5 That Regulates Axon Guidance, Synapse Maturation, and Cell Migration -- Cdk5 in Presynapses -- Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release -- Cdk5 in Dendrite and Synapse Development: Emerging Role as a Modulator of Receptor Tyrosine Kinase Signaling -- Cyclin-Dependent Kinase 5 (Cdk5) Modulates Signal Transduction Pathways Regulating Neuronal Survival -- CDK5 and Mitochondrial Cell Death Pathways -- Regulation and Function of Cdk5 in the Nucleus -- Cdk5 May Be an Atypical Kinase, but Not in the Way You Think -- Cdk5 and Neuregulin-1 Signaling -- Cyclin-Dependent Kinase 5 and Insulin Secretion -- Protein–Protein Interactions Involving the N-Terminus of p35 -- The Kinase Activity of Cdk5 and Its Regulation -- The Structural Bases of CDK5 Activity -- Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting -- Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory -- Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration -- Cdk5 as a Drug Target for Alzheimer’s Disease.
520			_aCyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.
650		0	_aMedicine.
650		0	_aNeurosciences.
650		0	_aCell biology.
650		0	_aDevelopmental biology.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
650	2	4	_aCell Biology.
650	2	4	_aDevelopmental Biology.
700	1		_aTsai, Li-Huei. _eeditor.
700	1		_aIp, Nancy Y. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387788869
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-78887-6
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c503727 _d503727