000			03145nam a22004575i 4500
001			978-0-387-77576-0
003			DE-He213
005			20161121230752.0
007			cr nn 008mamaa
008			100301s2008 xxu| s |||| 0|eng d
020			_a9780387775760 _9978-0-387-77576-0
024	7		_a10.1007/978-0-387-77576-0 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
245	1	0	_aGenomic Imprinting _h[electronic resource] / _cedited by Jon F. Wilkins.
264		1	_aNew York, NY : _bSpringer New York, _c2008.
300			_aXVIII, 126 p. 17 illus., 1 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v626
505	0		_aDNA Methylation Reprogramming in the Germ Line -- Control of Imprinting at the Gnas Cluster -- The GNAS Locus and Pseudohypoparathyroidism -- Imprinted Genes, Postnatal Adaptations and Enduring Effects on Energy Homeostasis -- What Are Imprinted Genes Doing in the Brain? -- Genomic Imprinting and Human Psychology: Cognition, Behavior and Pathology -- Genomic Imprinting in Plants -- Imprinted Genes and Human Disease: An Evolutionary Perspective -- Evolutionary Theories of Imprinting— Enough Already!.
520			_aGenomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father. This difference in expression strategy correlates with differences in the epigenetic state of the two alleles. These epigenetic differences include DNA methylation at CpG dinucleotides, as well as modifications on the histones associated with the locus. In the simplest possible cases, the promoter region of the imprinted gene is methylated during oogenesis, but not spermatogenesis (or vice versa). This methylation (and its accompanying histone modifications) results in inactivation of the modified allele. Of course, most imprinted genes do not fall into this simplest case. The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field (which would necessarily span multiple books). Rather, the book covers on some of the more recent advances, with the goal of drawing attention to some of the emerging subtleties and complexities associated with imprinted genes.
650		0	_aMedicine.
650		0	_aHuman genetics.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
700	1		_aWilkins, Jon F. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387775753
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v626
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-77576-0
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c503713 _d503713