000 04272nam a22004335i 4500
001 978-0-387-77574-6
003 DE-He213
005 20161121230752.0
007 cr nn 008mamaa
008 100301s2008 xxu| s |||| 0|eng d
020 _a9780387775746
_9978-0-387-77574-6
024 7 _a10.1007/978-0-387-77574-6
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aSunlight, Vitamin D and Skin Cancer
_h[electronic resource] /
_cedited by Jörg Reichrath.
264 1 _aNew York, NY :
_bSpringer New York,
_c2008.
300 _aXXI, 323 p. 79 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v624
505 0 _aSunlight, UV-Radiation, Vitamin D and Skin Cancer: How Much Sunlight Do We Need? -- Solar Ultraviolet Irradiance and Cancer Incidence and Mortality -- Vitamin D Status and Cancer Incidence and Mortality -- Sun Exposure and Cancer Survival in Norway: Changes in the Risk of Death with Season of Diagnosis and Latitude -- Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes -- Ultraviolet Exposure Scenarios: Risks of Erythema from Recommendations on Cutaneous Vitamin D Synthesis -- At What Time Should One Go Out in the Sun? -- Epidemiology of Melanoma and Nonmelanoma Skin Cancer—The Role of Sunlight -- Ultraviolet Radiation and Malignant Melanoma -- Solar UV Exposure and Mortality from Skin Tumors -- Health Initiatives for the Prevention of Skin Cancer -- Sunscreens -- UV Damage and DNA Repair in Malignant Melanoma and Nonmelanoma Skin Cancer -- Role of Viruses in the Development of Squamous Cell Cancer and Melanoma -- Melanoma and Nonmelanoma Skin Cancers and the Immune System -- Solar UV-Radiation, Vitamin D and Skin Cancer Surveillance in Organ Transplant Recipients (OTRs) -- Histology of Melanoma and Nonmelanoma Skin Cancer -- Cytogenetics of Melanoma and Nonmelanoma Skin Cancer -- Molecular Biology of Basal and Squamous Cell Carcinomas -- Molecular Biology of Malignant Melanoma -- p53 Protein and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer -- Apoptosis and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer -- Treatment of Melanoma and Nonmelanoma Skin Cancer.
520 _aUV exposuie represents the most important risk factor for the development of nonmelanoma skin cancer. Additionally, assessment of sun exposure parameters has consistently shown an association between the development of malignant melanoma and short term, intense UV exposure, particularly burning in childhood. As a consequence, protection of the skin from UV exposure is an integral part of skin cancer prevention programs. However, more chronic, less intense UV exposure has not been found to be a risk factor for melanoma and in fact has been found in some studies to be protective. Moreover, 90% of all requisite vitamin D is formed within the skin through the action of the sun—a serious problem—for a connection between vitamin D deficiency and various types of cancer (e. g. , colon, prostate and breast cancers) has been demonstrated in a large number of studies. Hence, the - sociation between vitamin D deficiency and various internal malignancies has now opened a debate among dermatologists and other clinicians how to balance between positive and negative effects of solar and artificial UV exposure. The goal of this volume is to provide a comprehensive, highly readable overview of our present knowledge of positive and negative effects of UV exposure, with a focus on vitamin D and skin cancer.
650 0 _aMedicine.
650 0 _aCancer research.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
700 1 _aReichrath, Jörg.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387775739
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v624
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-77574-6
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503712
_d503712