000			03697nam a22004095i 4500
001			978-0-387-76761-1
003			DE-He213
005			20161121230752.0
007			cr nn 008mamaa
008			100715s2008 xxu| s |||| 0|eng d
020			_a9780387767611 _9978-0-387-76761-1
024	7		_a10.1007/978-0-387-76761-1 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
245	1	0	_aReelin Glycoprotein _h[electronic resource] : _bStructure, Biology and Roles in Health and Disease / _cedited by S. Hossein Fatemi.
264		1	_aNew York, NY : _bSpringer New York, _c2008.
300			_aXXIII, 443 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThe Reelin Gene and Its Functions in Brain Development -- Apolipoprotein E Receptor 2 and Very-Low-Density Lipoprotein Receptor: An Overview -- Chemistry of Reelin -- The C-Terminal Region of Reelin: Structure and Function -- Crystal Structure of Reelin Repeats -- Comparative Anatomy and Evolutionary Roles of Reelin -- Reelin/Dab1 Signaling in the Developing Cerebral Cortex -- Ultrastructural Localization of Reelin -- Reelin and Cyclin-Dependent Kinase 5 -- Reelin and the Cerebellum -- Reelin and Radial Glial Cells -- Reelin and Cognition -- Protein Kinases and Signaling Pathways that Are Activated by Reelin -- The Relationship of Oxytocin and Reelin in the Brain -- Reelin and Thyroid Hormone -- A Tale of Two Genes: Reelin and BDNF -- Reelin, Liver, and Lymphatics -- Reelin and Cajal-Retzius Cells -- Reelin and Odontogenesis -- Homozygous and Heterozygous Reeler Mouse Mutants -- Reelin and Lissencephaly -- The Role of Reelin in Etiology and Treatment of Psychiatric Disorders -- Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia -- Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder -- Reelin Gene Polymorphisms in Autistic Disorder -- Alzheimer’s Disease and Reelin -- Reelin and Stroke -- Reelin and Pancreatic Cancer.
520			_aReelin glycoprotein is a major secretory protein with important roles in embryogenesis and during adult life. Reelin gene mutations or deficiency of the protein product cause abnormal cortical development and reelin signaling impairment in brain. Since the first discovery of the reelin mutant mouse in 1951 by Falconer, and later discovery of the gene for reelin in 1995, there has been an explosion of new knowledge about this important molecule. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease, written by an international panel of experts, summarizes the state of the knowledge on various aspects of reelin. Topics include the reelin gene and its receptors, downstream effector molecules in reelin signaling cascade, chemistry and structure of reelin, comparative anatomy of reelin, presence of reelin in various body tissues, reelin mutations, and abnormalities of reelin production in neuropsychiatric disorders and cancer. This book will serve as a foundation for analysis of this emerging novel protein for all neuroscientists and clinicians.
650		0	_aMedicine.
650		0	_aNeurosciences.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
700	1		_aFatemi, S. Hossein. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387767604
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-76761-1
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c503705 _d503705