000			03542nam a22005295i 4500
001			978-0-387-72232-0
003			DE-He213
005			20161121230750.0
007			cr nn 008mamaa
008			100602s2007 xxu| s |||| 0|eng d
020			_a9780387722320 _9978-0-387-72232-0
024	7		_a10.1007/978-0-387-72232-0 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
245	1	0	_aMucosal Immune Defense: Immunoglobulin A _h[electronic resource] / _cedited by Charlotte Slayton Kaetzel.
264		1	_aBoston, MA : _bSpringer US, _c2007.
300			_aXVI, 434 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThe Structure of IgA -- IgA Plasma Cell Development -- Epithelial Transport of IgA by the Polymeric Immunoglobulin Receptor -- Fc Receptors for IgA -- Regulation of the Mucosal IgA System -- Biological Functions of IgA -- Protection of Mucosal Epithelia by IgA: Intracellular Neutralization and Excretion of Antigens -- Novel Functions for Mucosal SIgA -- IgA and Antigen Sampling -- IgA and Intestinal Homeostasis -- IgA and Respiratory Immunity -- IgA and Reproductive Tract Immunity -- IgA-Associated Diseases -- Mucosal SIgA Enhancement: Development of Safe and Effective Mucosal Adjuvants and Mucosal Antigen Delivery Vehicles -- Recombinant IgA Antibodies.
520			_aAntibodies of the IgA class form the front line of immune defense at mucosal surfaces lining the gastrointestinal, respiratory and genital tracts. These IgA antibodies promote peaceful co-existence with beneficial microorganisms, such as gut bacteria that assist in digestion and nutrient production, while selectively neutralizing pathogenic microorganisms and harmful environmental substances. This book, authored by international experts in the field of IgA immunology, presents a comprehensive and timely overview of current knowledge of IgA structure and function. Topics include the basic science of IgA biochemistry and molecular biology, general and tissue-specific aspects of IgA function, and the clinical relevance of IgA in infection, autoimmunity, immunodeficiency and cancer. The final chapters describe state-of-the art applications of molecular genetics for the production of vaccines and therapeutics targeting IgA. The unique focus on IgA, the most abundant molecule in the mucosal immune system, differentiates this book from more general texts in the area of mucosal immunology. This book should be useful for researchers, educators, clinicians and students interested in a concise source of up-to-date information on the central role of IgA in mucosal immune defense.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aPharmacology.
650		0	_aVirology.
650		0	_aAllergy.
650		0	_aInfectious diseases.
650		0	_aMicrobiology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aMicrobiology.
650	2	4	_aInfectious Diseases.
650	2	4	_aVirology.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aAllergology.
700	1		_aKaetzel, Charlotte Slayton. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387722313
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-72232-0
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c503655 _d503655