000 03619nam a22004815i 4500
001 978-0-387-70630-6
003 DE-He213
005 20161121230749.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 _a9780387706306
_9978-0-387-70630-6
024 7 _a10.1007/978-0-387-70630-6
_2doi
050 4 _aQH573-671
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
245 1 0 _aTNF Receptor Associated Factors (TRAFs)
_h[electronic resource] /
_cedited by Hao Wu.
264 1 _aNew York, NY :
_bSpringer New York,
_c2007.
300 _aXIX, 206 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v597
505 0 _aPhylogeny of the TRAF/MATH Domain -- TRAF1 and Its Biological Functions -- Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5 -- TRAF3 and Its Biological Function -- TRAF4, the Unique Family Member -- Characteristics and Biological Functions of TRAF6 -- Ubiquitination and TRAF signaling -- Structural Revelations of TRAF2 Function in TNF Receptor Signaling Pathway -- Protein-Protein Interactions in TRAF3 -- Molecular Basis for the Unique Specificity of TRAF6 -- TRAF Proteins in CD40 Signaling -- TRAFs in RANK Signaling -- The LT?R Signaling Pathway -- LMP1 TRAFficking Activates Growth and Survival pathways -- Targeting TRAFs for Therapeutic Intervention.
520 _aIt has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer. TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.
650 0 _aLife sciences.
650 0 _aComputer security.
650 0 _aCell biology.
650 0 _aDevelopmental biology.
650 1 4 _aLife Sciences.
650 2 4 _aCell Biology.
650 2 4 _aDevelopmental Biology.
650 2 4 _aSystems and Data Security.
700 1 _aWu, Hao.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387706290
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v597
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-70630-6
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503625
_d503625