000			03374nam a22005055i 4500
001			978-0-387-69132-9
003			DE-He213
005			20161121230749.0
007			cr nn 008mamaa
008			100301s2008 xxu| s |||| 0|eng d
020			_a9780387691329 _9978-0-387-69132-9
024	7		_a10.1007/978-0-387-69132-9 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
245	1	0	_aMouse Models of Human Blood Cancers _h[electronic resource] : _bBasic Research and Pre-clinical Applications / _cedited by Shaoguang Li.
264		1	_aNew York, NY : _bSpringer US, _c2008.
300			_aX, 293 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aMouse Models of Myeloproliferative Disease Associated with Mutant JAK2 Tyrosine Kinase: Insights into Pathophysiology and Therapy -- Genetic Modeling of Human Blood Cancers in Mice -- Murine Models of Hematopoietic Disease: Pathologic Analysis and Characterization -- Mechanisms of DNA Double-Strand Break Repair in Hematopoietic Homeostasis and Oncogenesis -- Modeling Human Leukemia Using Immune-Compromised Mice -- Dietary Restriction: A Model System Probing the Cell Fate Decision Between Cancer and Senescence -- Modeling Human Philadelphia Chromosome-Positive Leukemia in Mice -- Mouse Models of Human Mature B-Cell and Plasma Cell Neoplasms -- Genetic and Virological Predisposition to Pre-B Lymphomagenesis in SL/Kh -- Animal Cancer Models in Anticancer Drug Discovery and Development -- DGL Global Strategies in DNA Microarray Gene Expression Analysis and Data Mining for Human Blood Cancers.
520			_aAlthough it remains an open question among some people whether mice and humans are similar in disease development, the laboratory mouse has emerged as the preeminent animal model for human diseases. This is underscored by the recently completed mouse and human genome projects, which have revealed that mice and humans share the vast majority of their genes, and thus get many of the same diseases, and for the same reasons. Emphasizing why mouse models are valuable in vivo systems for understanding disease mechanisms and developing therapeutic strategies for human blood cancers, "Mouse Models of Human Blood Cancers: Basic Research and Pre-clinical Applications," edited by Shaoguang Li, aims on presenting thorough analyses of the pathological features and the molecular bases of several major types of blood cancer and to describe translational research using mouse cancer models.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aLaboratory medicine.
650		0	_aBiochemistry.
650		0	_aCell biology.
650		0	_aAnimal genetics.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aCell Biology.
650	2	4	_aAnimal Genetics and Genomics.
650	2	4	_aLaboratory Medicine.
650	2	4	_aAnimal Biochemistry.
700	1		_aLi, Shaoguang. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387691305
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-69132-9
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c503618 _d503618