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001 978-0-387-49931-4
003 DE-He213
005 20161121230748.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 _a9780387499314
_9978-0-387-49931-4
024 7 _a10.1007/978-0-387-49931-4
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aFarooqui, Akhlaq A.
_eauthor.
245 1 0 _aGlycerophospholipids in the Brain
_h[electronic resource] :
_bPhospholipases A2 in Neurological Disorders /
_cby Akhlaq A. Farooqui, Lloyd A. Horrocks.
264 1 _aNew York, NY :
_bSpringer New York,
_c2007.
300 _aXVI, 394 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPhospholipid Metabolism in Brain -- Ether Lipids in Brain -- Phospholipases A2 in Brain -- Roles of Phospholipases A2 in Brain -- Arachidonic Acid and Its Metabolites in Brain -- Docosahexaenoic Acid and Its Metabolites in Brain -- Nonenzymic Metabolites of Arachidonate and Docosahexaenoate in Brain -- Lyso-Glycerophospholipids -- Lysophosphatidic Acid and Its Metabolism in Brain -- Involvement of Phospholipids and Phospholipases A2 -- Inhibitors of Phospholipases A2 and Their Use for the Treatment of Neurological Disorders -- Assay Methods for Phospholipase A2 Activities in Brain -- Glycerophospholipids and Phospholipases A2 in Neuropsychiatric Disorders -- Future Perspectives: Metabolic and Functional Aspects of Neural Membrane Glycerophospholipids.
520 _aGlycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders Akhlaq A. Farooqui and Lloyd A. Horrocks Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders provides a synthesis of material on the metabolism of phospholipids in the brain which has previously only been available in a scattered number of original papers and reviews. Here, the research of over 25 years is collected in one volume from two of the leading researchers in the field— Akhlaq A. Farooqui and Lloyd A. Horrocks Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders comprehensively describes: metabolism in brain of glycerophospholipids, including those containing a vinyl ether group (plasmalogens) cutting-edge information on the properties and roles of phospholipases A2 in the central nervous system release by phospholipases A2 of second messengers (arachidonic acid, docosahexaenoic acid, and lysophospholipid) from neural membrane phospholipids and their neurochemical effects on brain metabolism and function involvement of phospholipases A2 in neurological and neuropsychiatric disorders, and the use of phospholipase A2 inhibitors for the treatment of diseases associated with altered phospholipid metabolism methods for the assays of phospholipases A2 and their clinical significance This unique volume will be invaluable not only to those interested in biochemical properties of phospholipases A2, but also their involvement in neurological disorders. Students will benefit from it as a supplement for a range of neuroscience courses. Clinicians will find it invaluable as well for understanding molecular aspects of neurodegeneration in acute neural trauma (stroke) and neurodegenerative diseases (Alzheimer disease) that are mediated by phospholipases A2. The information in Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders is presented in a lively manner that has never been attempted until now in this specialized format. It will be the essential text for the authoritative research in the field. About the Authors Akhlaq A. Farooqui and Lloyd A. Horrocks are leaders in the fields of phospholipid metabolism and phospholipases A2 in brain. They have published cutting edge research on phospholipases A2 and their involvement in neurological disorders in brain tissue. In collaboration with Dr. Yutaka Hirashima, they have discovered a plasmalogen-selective phospholipase A2 in brain. They have also studied phospholipids composition of neural membranes and activities of phospholipases A2 in neural membranes. Lloyd A. Horrocks is the founding editor of Molecular and Chemical Neuropathology and has edited seven books.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
700 1 _aHorrocks, Lloyd A.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387366029
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-49931-4
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503604
_d503604