000 03691nam a22004575i 4500
001 978-0-387-39978-2
003 DE-He213
005 20161121230747.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 _a9780387399782
_9978-0-387-39978-2
024 7 _a10.1007/978-0-387-39978-2
_2doi
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
245 1 0 _aMicroarray Technology and Cancer Gene Profiling
_h[electronic resource] /
_cedited by Simone Mocellin.
264 1 _aNew York, NY :
_bSpringer New York,
_c2007.
300 _aXVIII, 159 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v593
505 0 _aMicroarray Technology -- Manufacturing of Microarrays -- Technological Platforms for Microarray Gene Expression Profiling -- Principles of Gene Microarray Data Analysis -- Gaining Weights ... and Feeling Good about It! -- Complementary Techniques -- Complementary Techniques -- Complementary Techniques -- Applications in the Oncology Field -- Microarrays for Cancer Diagnosis and Classification -- Gene Profiling for the Prediction of Tumor Response to Treatment -- Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs -- SNP and Mutation Analysis -- Cancer Development and Progression -- Gene Expression Profiling in Malignant Lymphomas -- Tumor Immunology.
520 _aCancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. Accordingly, DNA array, as other high throughput technologies, might catalyze and ultimately accelerate the development of knowledge in tumor cell biology. Although in its infancy, the implementation of DNA array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents. Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aOncology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
650 2 4 _aCancer Research.
700 1 _aMocellin, Simone.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387399775
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v593
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-39978-2
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503585
_d503585