000 03879nam a22005055i 4500
001 978-0-387-39717-7
003 DE-He213
005 20161121230747.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 _a9780387397177
_9978-0-387-39717-7
024 7 _a10.1007/978-0-387-39717-7
_2doi
050 4 _aQD431-431.7
072 7 _aPSBC
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572.6
_223
245 1 0 _aCell Stress Proteins
_h[electronic resource] /
_cedited by Stuart K. Calderwood.
264 1 _aNew York, NY :
_bSpringer New York,
_c2007.
300 _aXVI, 460 p. 38 illus., 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProtein Reviews ;
_v7
505 0 _aIntroduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease -- Introduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease -- Stress Response and Molecular Chaperones -- Biology of the Heat Shock Response and Stress Conditioning -- Bacterial Stress Sensors -- Unfolded Protein Response: Contributions to Development and Disease -- Molecular Mechanisms of Stress Protein Expression -- Genetic Models of HSF Function -- HSF1 and HSP Gene Regulation -- Cellular Stress Proteins -- Small Heat Shock Proteins in Physiological and Stress-Related Processes -- Large Mammalian hsp70 Family Proteins, hsp110 and grp170, and Their Roles in Biology and Cancer Therapy -- Molecular Chaperones and Protein Folding -- Regulation of Hsp70 Function: Hsp40 Co-Chaperones and Nucleotide Exchange Factors -- Protein Disassembly by Hsp40-Hsp70 -- Mammalian HSP40/DnaJ Chaperone Proteins in Cytosol -- Role of Molecular Chaperones in Cell Regulation -- FKBP Co-Chaperones in Steroid Receptor Complexes -- Up and Down Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP -- Role of Cdc37 in Protein Kinase Folding -- Intracellular and Extracellular Stress Proteins in Human Disease -- Targeting Hsp90 in Cancer and Neurodegenerative Disease -- gp96 and Tumor Immunity -- Immunoregulatory Activities of Extracellular Stress Proteins -- Heat Shock Proteins and Neurodegenerative Diseases -- Heat Shock Proteins in the Progression of Cancer.
520 _aThis comprehensive volume, written by experts in the field, provides a current understanding of the molecular properties of the heat shock proteins and their roles in health and disease. Cell Stress Proteins includes advances in several aspects of stress protein research, with chapters ranging from basic studies of the role of heat shock proteins in protein folding to reviews examining the breakdown of stress protein regulation during disease. It also provides analysis of the biochemical and molecular properties of heat shock proteins which can be utilized in evaluating their role in human physiology and pathology. Cell Stress Proteins is an ideal book for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
650 0 _aLife sciences.
650 0 _aImmunology.
650 0 _aBiochemistry.
650 0 _aProteins.
650 0 _aMicrobiology.
650 1 4 _aLife Sciences.
650 2 4 _aProtein Science.
650 2 4 _aMicrobiology.
650 2 4 _aImmunology.
650 2 4 _aBiochemistry, general.
700 1 _aCalderwood, Stuart K.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387397146
830 0 _aProtein Reviews ;
_v7
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-39717-7
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503580
_d503580