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001 978-0-387-36534-3
003 DE-He213
005 20161121230747.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 _a9780387365343
_9978-0-387-36534-3
024 7 _a10.1007/978-0-387-36534-3
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aProtein Misfolding, Aggregation, and Conformational Diseases
_h[electronic resource] :
_bPart B: Molecular Mechanisms of Conformational Diseases /
_cedited by Vladimir N. Uversky, Anthony L. Fink.
264 1 _aBoston, MA :
_bSpringer US,
_c2007.
300 _aXXVI, 538 p. 112 illus., 14 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProtein Reviews ;
_v6
505 0 _aAltered Protein Structure and Enhanced Aggregation/Deposition -- The Pathogenesis of Alzheimer’s Disease: General Overview -- Free Radicals, Metal Ions, and A? Aggregation and Neurotoxicity -- Progress in Understanding the Mechanisms of Neuronal Dysfunction and Degeneration in Parkinson’s Disease -- ?-Synuclein Aggregation and Parkinson’s Disease -- Cell Biology of ?-Synuclein: Implications in Parkinson’s Disease and Other Lewy Body Diseases -- Pathogenesis of Prion Diseases -- Mammalian Prion Protein -- The Yeast Prion Proteins Sup35p and Ure2p -- Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis -- Pancreatic Islet Amyloid and Diabetes -- ?2-Microglobulin and Dialysis-Related Amyloidosis -- Serum Amyloid A and AA Amyloidosis -- Point Mutations and Enhanced Protein Deposition -- Transthyretin and the Transthyretin Amyloidoses -- Human Lysozyme -- Serpins and the Diversity of Conformational Diseases -- Altered Protein Structure and Impaired Function -- Human Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis -- Understanding the Effects of Cancer-Associated Mutations in the Tumor Suppressor Protein p53: Structural Consequences of Mutations and Possible Ways of Rescuing Oncogenic Mutants -- Changes in Supramolecular Structure -- Protein Aggregation in Muscle Fibers and Respective Neuromuscular Disorders -- Muscular Dystrophies and Protein Mutations -- The Functional Consequences of Dystrophin Deficiency in Skeletal Muscles -- Eye Lens Proteins and Cataracts -- Altered Protein Structure and Changes in Cellular/Nuclear Function -- Glutamine/Asparagine-Rich Regions in Proteins and Polyglutamine Diseases -- Mechanistic Insights into the Polyglutamine Ataxias -- Molecular Pathogenesis of the Polyglutamine Disease: Spinal and Bulbar Muscular Atrophy -- Post-Translational Modification and Protein Conformational Diseases -- Protein Glycation and Cataract: A Conformational Disease -- Defective Glycosylation and Muscular Dystrophies.
520 _aProtein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is a comprehensive volume providing a broad and detailed discussion of the relationships of protein misfolding and aggregation with the pathogenesis of numerous conformational diseases. While the Part A was dedicated to the description of the general mechanisms underlying protein misfolding, aggregation, and development of protein deposition disorders, this volume summarizes recent achievements in the understanding of the molecular mechanisms of conformational diseases. Research indicates that these mechanisms are highly diverse and range from the altered protein structure leading to the enhanced propensity for aggregation/deposition or the impaired functions and ending with changes in supra-molecular structures or posttranslational modification. Protein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is an ideal book for pharmaceutical scientists, molecular and cellular biologists, biochemists, immunologists, protein scientists, and biophysicists.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aCell Biology.
700 1 _aUversky, Vladimir N.
_eeditor.
700 1 _aFink, Anthony L.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387365299
830 0 _aProtein Reviews ;
_v6
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-36534-3
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503572
_d503572