000 04019nam a22005535i 4500
001 978-0-387-36514-5
003 DE-He213
005 20161121230747.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 _a9780387365145
_9978-0-387-36514-5
024 7 _a10.1007/978-0-387-36514-5
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
245 1 0 _aSigma Receptors
_h[electronic resource] :
_bChemistry, Cell Biology and Clinical Implications /
_cedited by Tsung-Ping Su, Rae R. Matsumoto, Wayne D. Bowen.
264 1 _aBoston, MA :
_bSpringer US,
_c2007.
300 _aX, 413 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _a? Receptors: Historical Perspective and Background -- Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands -- Irreversible ? Compounds -- Pharmacophore Models for ?1 Receptor Binding -- Cloning of ?1 Receptor and Structural Analysis of Its Gene and Promoter Region -- Site-Directed Mutagenesis -- ? Receptor Modulation of Ion Channels -- Subcellular Localization and Interacellular Dynamics of ?1 Receptors -- Intracellular Signaling and Synaptic Plasticity -- Modulation of Classical Neurotransmitter Systems by ? Receptors -- ?2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics -- Cognitive Effects of ? Receptor Ligands -- ? Receptors and Scizophrenia -- Potential Role of ? Ligands and Neurosteroids in Major Depression -- ? Receptors and Drug Abuse -- ?1 Receptors and the Modulation of Opiate Analgesics -- ? Receptors in the Immune System: Implications for Potential Therapeutic Intervention - An Overview -- ? Receptors and Gastrointestinal Function.
520 _aSigma receptors are promising drug development targets for a host of neurological, psychiatric, oncological, immunological, cardiovascular, ophthalmological, and gastrointestinal disorders. They are structurally unique proteins that are distinct from classical G protein-coupled receptors, ionotropic receptors, or receptor tyrosine kinases. With two subtypes currently known, they modulate cell survival and excitability, and subserve many critical functions in the body. Endogenous ligands for these receptors are unknown, though current clues point to neurosteroids. This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of sigma receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point for the development of exciting, new research. Sigma Receptors: Chemistry, Cell Biology and Clinical Implications will be a valuable tool for pharmacologists, medicinal chemists, cell biologists, molecular biologists, clinicians, and others interested in a concise, state-of-the-art overview of the sigma receptor field with a particular view towards novel therapeutic advances.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aPharmacology.
650 0 _aChemistry.
650 0 _aPsychiatry.
650 0 _aBiochemistry.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aChemistry/Food Science, general.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aBiochemistry, general.
650 2 4 _aCell Biology.
650 2 4 _aPsychiatry.
700 1 _aSu, Tsung-Ping.
_eeditor.
700 1 _aMatsumoto, Rae R.
_eeditor.
700 1 _aBowen, Wayne D.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387365121
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-36514-5
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c503570
_d503570